Chronic consumption of alcohol and its damaging effects on the body
Hronicno konzumiranje alkohola i njegovi stetni uticaji na organizam
Апстракт
It is widely accepted that alcohol metabolism passes through different mechanisms: alcohol dehydrogenase (ADH) activity in stomach epithelial cells, activity of ADH in the liver, microsomal-ethanol-oxydizing system (MEOS), hepatocyte catalase activity, and nonoxydizing metabolic pathway (production of fatty acid ethylesters). Alcohol causes numerous direct and indirect toxic effects on human organism. The first are directed to epithelial cells of stomach and liver cells, as well as the generation of excessive amounts of metabolites: NADH, acetaldehyde and acetate. These amounts of NADH lead to hyperlactacidaemia, hypoalbuminaemia and fat infiltration to the liver. The activity of MEOS causes drug metabolism changes in the liver and increased rate of hepatotoxic and cancerous substances. Acetaldehyde increases lipid peroxidation, immunity disorders, decrease in enzymatic activities and restoration of nucleoproteins, while acetate decreases lipolitic processes in cells.
Извор:
Srpski arhiv za celokupno lekarstvo, 1996, 124, 9-10, 260-266Издавач:
- Srpsko lekarsko društvo, Beograd
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Petrović, Gordana P. AU - Ristić, D. AU - Ristić, S. PY - 1996 UR - http://rimi.imi.bg.ac.rs/handle/123456789/22 AB - It is widely accepted that alcohol metabolism passes through different mechanisms: alcohol dehydrogenase (ADH) activity in stomach epithelial cells, activity of ADH in the liver, microsomal-ethanol-oxydizing system (MEOS), hepatocyte catalase activity, and nonoxydizing metabolic pathway (production of fatty acid ethylesters). Alcohol causes numerous direct and indirect toxic effects on human organism. The first are directed to epithelial cells of stomach and liver cells, as well as the generation of excessive amounts of metabolites: NADH, acetaldehyde and acetate. These amounts of NADH lead to hyperlactacidaemia, hypoalbuminaemia and fat infiltration to the liver. The activity of MEOS causes drug metabolism changes in the liver and increased rate of hepatotoxic and cancerous substances. Acetaldehyde increases lipid peroxidation, immunity disorders, decrease in enzymatic activities and restoration of nucleoproteins, while acetate decreases lipolitic processes in cells. PB - Srpsko lekarsko društvo, Beograd T2 - Srpski arhiv za celokupno lekarstvo T1 - Chronic consumption of alcohol and its damaging effects on the body T1 - Hronicno konzumiranje alkohola i njegovi stetni uticaji na organizam EP - 266 IS - 9-10 SP - 260 VL - 124 UR - https://hdl.handle.net/21.15107/rcub_rimi_22 ER -
@article{ author = "Petrović, Gordana P. and Ristić, D. and Ristić, S.", year = "1996", abstract = "It is widely accepted that alcohol metabolism passes through different mechanisms: alcohol dehydrogenase (ADH) activity in stomach epithelial cells, activity of ADH in the liver, microsomal-ethanol-oxydizing system (MEOS), hepatocyte catalase activity, and nonoxydizing metabolic pathway (production of fatty acid ethylesters). Alcohol causes numerous direct and indirect toxic effects on human organism. The first are directed to epithelial cells of stomach and liver cells, as well as the generation of excessive amounts of metabolites: NADH, acetaldehyde and acetate. These amounts of NADH lead to hyperlactacidaemia, hypoalbuminaemia and fat infiltration to the liver. The activity of MEOS causes drug metabolism changes in the liver and increased rate of hepatotoxic and cancerous substances. Acetaldehyde increases lipid peroxidation, immunity disorders, decrease in enzymatic activities and restoration of nucleoproteins, while acetate decreases lipolitic processes in cells.", publisher = "Srpsko lekarsko društvo, Beograd", journal = "Srpski arhiv za celokupno lekarstvo", title = "Chronic consumption of alcohol and its damaging effects on the body, Hronicno konzumiranje alkohola i njegovi stetni uticaji na organizam", pages = "266-260", number = "9-10", volume = "124", url = "https://hdl.handle.net/21.15107/rcub_rimi_22" }
Petrović, G. P., Ristić, D.,& Ristić, S.. (1996). Chronic consumption of alcohol and its damaging effects on the body. in Srpski arhiv za celokupno lekarstvo Srpsko lekarsko društvo, Beograd., 124(9-10), 260-266. https://hdl.handle.net/21.15107/rcub_rimi_22
Petrović GP, Ristić D, Ristić S. Chronic consumption of alcohol and its damaging effects on the body. in Srpski arhiv za celokupno lekarstvo. 1996;124(9-10):260-266. https://hdl.handle.net/21.15107/rcub_rimi_22 .
Petrović, Gordana P., Ristić, D., Ristić, S., "Chronic consumption of alcohol and its damaging effects on the body" in Srpski arhiv za celokupno lekarstvo, 124, no. 9-10 (1996):260-266, https://hdl.handle.net/21.15107/rcub_rimi_22 .