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Prikaz rezultata 11-20 od 464
Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
(Bentham Science Publ Ltd, Sharjah, 2012)
Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported ...
Effects of Nitric Oxide on Red Blood Cell Development and Phenotype
(Current Topics in Developmental Biology, 2008)
Nitric oxide (NO) is a diffusible free radical generated primarily by NO synthases (NOS), isoenzymes that convert the l-arginine and molecular oxygen to citrulline and NO in cells. Endothelial cells as well as macrophages, ...
Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells
(Amer Soc Hematology, Washington, 2006)
Hydroxyurea is a cell-cycle-specific drug that has been used to treat myeloproliferative diseases and sickle cell anemia. We have recently shown that hydroxyurea, like nitric oxide (NO)-donor compounds, increased cGMP ...
Lower Serum Paraoxonase-1 Activity Is Related to Linoleic and Docosahexanoic Fatty Acids in Type 2 Diabetic Patients
(Elsevier Science Inc, New York, 2012)
Background. Serum paraoxonase-1(PON-1) activity is decreased in clinical conditions associated with low high-density lipoprotein cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation, as in ...
Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity
(Academic Press Inc Elsevier Science, San Diego, 2007)
Recent reports have identified the proteasome as the primary degradation pathway for inducible, neuronal and endothelial nitric oxide synthase (NOS). We have demonstrated that hydroxyurea increased nitric oxide (NO) ...
ROS-NF kappa I' mediates TGF-beta 1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion
(Springer, Dordrecht, 2010)
TGF-beta 1 has been postulated as a pro-oncogenic factor in the late step of the tumoral progression. In transformed cells, TGF-beta 1 enhances the capacity to degrade the extracellular matrix, cell invasiveness and ...
Changes in movement variables associated with transient overshoot of the final position
(Routledge Journals, Taylor & Francis Ltd, Abingdon, 2000)
Transient overshoot (TO), which is assessed as the distance between the movement amplitude and the final position, was measured in a series of rapid, discrete elbow flexion movements performed under different distance and ...
Naltrexone prevents ethanol-induced changes in rat thymus
(Elsevier Science Inc, New York, 1996)
Ethanol is known to suppress the immune response, but the underlying mechanism accounting for the immunosuppression is not clearly elucidated yet. The purpose of this study was to investigate the effect of a single dose ...
Toxoplasma infection and pathological outcome of pregnancy
(Gynecologic & Obstetric Investigation, 1995)
To better evaluate the role of infection with Toxoplasma gondii in the outcome of pregnancy, 2,108 women with unsuccessful pregnancies (1,747 with spontaneous abortion, 187 with preterm delivery, 126 who delivered stillborn ...
Specific igm antibodies as parameters of toxoplasma infection in pregnancy
(Gynecologic & Obstetric Investigation, 1993)
The aim of this investigation was to determine the time of toxoplasma infection more precisely by using an indirect fluorescent antibody test and indirect hemagglutination test in 51 pregnant women whose Sabin-Feldman test ...