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Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro
(Ao Research Institute Davos-Ari, Davos, 2019)
Mesenchymal stem/stromal cells (MSCs) are an essential element of most modem tissue engineering and regenerative medicine approaches due to their multipotency and immunoregulatory functions. Despite the prospective value ...
Globin gene expression in correlation with G protein-related genes during erythroid differentiation
(Biomed Central Ltd, London, 2013)
Background: The guanine nucleotide binding protein (G protein)-coupled receptors (GPCRs) regulate cell growth, proliferation and differentiation. G proteins are also implicated in erythroid differentiation, and some of ...
Evidence for host genetic regulation of altered lipid metabolism in experimental toxoplasmosis supported with gene data mining results
(Public Library Science, San Francisco, 2017)
Toxoplasma gondii is one of the most successful parasites on Earth, infecting a wide array of mammals including one third of the global human population. The obligate intracellular protozoon is not capable of synthesizing ...
Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure
(Oxford Univ Press, Oxford, 2004)
Background. The relative roles of endothelin (ET)-1 and angiotensin (ANG) II in post-ischaemic acute renal failure (ARF) have not been fully established so far. With the aim of contributing to this goal, we assessed in ...
Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
(Hindawi Ltd, London, 2015)
Transforming growth factor-beta (TGF-beta) and oxidative stress/ReactiveOxygen Species (ROS) both have pivotal roles in health and disease. In this review we are analyzing the interplay between TGF-beta and ROS in tumorigenesis ...
Angiogenic factors are increased in circulating granulocytes and CD34(+) cells of myeloproliferative neoplasms
(Wiley-Blackwell, Hoboken, 2017)
It has been shown that angiogenesis and inflammation play an important role in development of most hematological malignancies including the myeloproliferative neoplasm (MPN). The aim of this study was to investigate and ...
Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
(Wiley, Hoboken, 2018)
Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of ...
Preparatory training attenuates drastic response of the insulin-like growth factor binding protein 1 at the point of maximal oxygen consumption in handball players
(Shanghai Univ Sport, Shanghai, 2017)
Background: Intensive exercise changes physiological need for glucose and several biochemical pathways responsible for its metabolism response. Among them are those which involve insulin, insulin-like growth factor (IGF-1), ...
Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress
(Springer Heidelberg, Heidelberg, 2019)
Purpose High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized ...
Babesia microti infection changes host spleen architecture and is cleared by a Th1 immune response
(Frontiers in Microbiology, 2018)
Babesia microti is a malaria-like parasite, which infects ~2000 people annually, such that babesiosis is now a notifiable disease in the United States. Immunocompetent individuals often remain asymptomatic and are tested ...