Hematopoietic stem cell transplantation monitoring in childhood. Hematological diseases in Serbia: STR-PCR techniques
2007
Аутори
Krstić, AleksandraStojković, O.
Guc-Scekić, Marija
Vujić, Dragana
Jevtić, Dragana
Varljen, Tanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Hematopoietic stem cell transplantation (HSCT) is a very successful method of treatment for children with different aquired or inborn diseases. The main goal of post-transplantation chimerism monitoring in HSCT is to predict negative events (such as disease relapse and graft rejection), in order to intervene with appropriate therapy and improve the probability of long-teen DFS (disease free survival). In this context, by quantifying the relative amounts of donor and recipient cells present in the peripheral blood sample, it can be determined if engraftment has taken place at all, or if full or mixed chimerism exists. In a group of patients who underwent hematopoietic stem cell transplantation at the Mother and Child Health Care Institute, we decided to use standard human identfication tests based on multiplex PCR analyses of short tandem repeats (STRs), as they are highly informative, sensitive, and fast and therefore represent an optimal methodological approach to engraftment analysis....
Кључне речи:
haematopoietic stem cells transplantation / chimerism / STR-PCR / hematological diseasesИзвор:
Archives of Biological Sciences, 2007, 59, 1, 23-27Издавач:
- Srpsko biološko društvo, Beograd, i dr.
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Krstić, Aleksandra AU - Stojković, O. AU - Guc-Scekić, Marija AU - Vujić, Dragana AU - Jevtić, Dragana AU - Varljen, Tanja PY - 2007 UR - http://rimi.imi.bg.ac.rs/handle/123456789/184 AB - Hematopoietic stem cell transplantation (HSCT) is a very successful method of treatment for children with different aquired or inborn diseases. The main goal of post-transplantation chimerism monitoring in HSCT is to predict negative events (such as disease relapse and graft rejection), in order to intervene with appropriate therapy and improve the probability of long-teen DFS (disease free survival). In this context, by quantifying the relative amounts of donor and recipient cells present in the peripheral blood sample, it can be determined if engraftment has taken place at all, or if full or mixed chimerism exists. In a group of patients who underwent hematopoietic stem cell transplantation at the Mother and Child Health Care Institute, we decided to use standard human identfication tests based on multiplex PCR analyses of short tandem repeats (STRs), as they are highly informative, sensitive, and fast and therefore represent an optimal methodological approach to engraftment analysis. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Hematopoietic stem cell transplantation monitoring in childhood. Hematological diseases in Serbia: STR-PCR techniques EP - 27 IS - 1 SP - 23 VL - 59 DO - 10.2298/ABS0701023K ER -
@article{ author = "Krstić, Aleksandra and Stojković, O. and Guc-Scekić, Marija and Vujić, Dragana and Jevtić, Dragana and Varljen, Tanja", year = "2007", abstract = "Hematopoietic stem cell transplantation (HSCT) is a very successful method of treatment for children with different aquired or inborn diseases. The main goal of post-transplantation chimerism monitoring in HSCT is to predict negative events (such as disease relapse and graft rejection), in order to intervene with appropriate therapy and improve the probability of long-teen DFS (disease free survival). In this context, by quantifying the relative amounts of donor and recipient cells present in the peripheral blood sample, it can be determined if engraftment has taken place at all, or if full or mixed chimerism exists. In a group of patients who underwent hematopoietic stem cell transplantation at the Mother and Child Health Care Institute, we decided to use standard human identfication tests based on multiplex PCR analyses of short tandem repeats (STRs), as they are highly informative, sensitive, and fast and therefore represent an optimal methodological approach to engraftment analysis.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Hematopoietic stem cell transplantation monitoring in childhood. Hematological diseases in Serbia: STR-PCR techniques", pages = "27-23", number = "1", volume = "59", doi = "10.2298/ABS0701023K" }
Krstić, A., Stojković, O., Guc-Scekić, M., Vujić, D., Jevtić, D.,& Varljen, T.. (2007). Hematopoietic stem cell transplantation monitoring in childhood. Hematological diseases in Serbia: STR-PCR techniques. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 59(1), 23-27. https://doi.org/10.2298/ABS0701023K
Krstić A, Stojković O, Guc-Scekić M, Vujić D, Jevtić D, Varljen T. Hematopoietic stem cell transplantation monitoring in childhood. Hematological diseases in Serbia: STR-PCR techniques. in Archives of Biological Sciences. 2007;59(1):23-27. doi:10.2298/ABS0701023K .
Krstić, Aleksandra, Stojković, O., Guc-Scekić, Marija, Vujić, Dragana, Jevtić, Dragana, Varljen, Tanja, "Hematopoietic stem cell transplantation monitoring in childhood. Hematological diseases in Serbia: STR-PCR techniques" in Archives of Biological Sciences, 59, no. 1 (2007):23-27, https://doi.org/10.2298/ABS0701023K . .