Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development
Samo za registrovane korisnike
2024
Autori
Trivanović, DrenkaVujačić, Marko
Labella, Rossella
Okić Đorđević, Ivana
Ćazić, Marija
Chernak, Brian
Jauković, Aleksandra
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Purpose of Review Along with a strong impact on skeletal integrity, bone marrow adipose tissue (BMAT) is an important
modulator of the adult hematopoietic system. This review will summarize the current knowledge on the causal relationship
between bone marrow (BM) adipogenesis and the development and progression of hematologic malignancies.
Recent Findings BM adipocytes (BMAds) support a number of processes promoting oncogenesis, including the evolution
of clonal hematopoiesis, malignant cell survival, proliferation, angiogenesis, and chemoresistance. In addition, leukemic
cells manipulate surrounding BMAds by promoting lipolysis and release of free fatty acids, which are then utilized by leu-
kemic cells via β-oxidation. Therefore, limiting BM adipogenesis, blocking BMAd-derived adipokines, or lipid metabolism
obstruction have been considered as potential treatment options for hematological malignancies.
Summary Leukemic stem cells rely heavily on BMAds within the structural BM... microenvironment for necessary signals
which foster disease progression. Further development of 3D constructs resembling BMAT at different skeletal regions are
critical to better understand these relationships in geometric space and may provide essential insight into the development of
hematologic malignancies within the BM niche. In turn, these mechanisms provide promising potential as novel approaches
to targeting the microenvironment with new therapeutic strategies.
Ključne reči:
Bone marrow adipose tissue / Adipogenesis / Bone / Hematopoiesis / Malignancy / LeukemiaIzvor:
Current Osteoporosis Reports, 2024Izdavač:
- Springer Nature
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200015 (Univerzitet u Beogradu, Institut za medicinska istraživanja) (RS-MESTD-inst-2020-200015)
DOI: 10.1007/s11914-024-00879-x
ISSN: 1544-2241
WoS: 001255153600001
Scopus: 2-s2.0-85197138673
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Trivanović, Drenka AU - Vujačić, Marko AU - Labella, Rossella AU - Okić Đorđević, Ivana AU - Ćazić, Marija AU - Chernak, Brian AU - Jauković, Aleksandra PY - 2024 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1516 AB - Purpose of Review Along with a strong impact on skeletal integrity, bone marrow adipose tissue (BMAT) is an important modulator of the adult hematopoietic system. This review will summarize the current knowledge on the causal relationship between bone marrow (BM) adipogenesis and the development and progression of hematologic malignancies. Recent Findings BM adipocytes (BMAds) support a number of processes promoting oncogenesis, including the evolution of clonal hematopoiesis, malignant cell survival, proliferation, angiogenesis, and chemoresistance. In addition, leukemic cells manipulate surrounding BMAds by promoting lipolysis and release of free fatty acids, which are then utilized by leu- kemic cells via β-oxidation. Therefore, limiting BM adipogenesis, blocking BMAd-derived adipokines, or lipid metabolism obstruction have been considered as potential treatment options for hematological malignancies. Summary Leukemic stem cells rely heavily on BMAds within the structural BM microenvironment for necessary signals which foster disease progression. Further development of 3D constructs resembling BMAT at different skeletal regions are critical to better understand these relationships in geometric space and may provide essential insight into the development of hematologic malignancies within the BM niche. In turn, these mechanisms provide promising potential as novel approaches to targeting the microenvironment with new therapeutic strategies. PB - Springer Nature T2 - Current Osteoporosis Reports T1 - Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development DO - 10.1007/s11914-024-00879-x ER -
@article{ author = "Trivanović, Drenka and Vujačić, Marko and Labella, Rossella and Okić Đorđević, Ivana and Ćazić, Marija and Chernak, Brian and Jauković, Aleksandra", year = "2024", abstract = "Purpose of Review Along with a strong impact on skeletal integrity, bone marrow adipose tissue (BMAT) is an important modulator of the adult hematopoietic system. This review will summarize the current knowledge on the causal relationship between bone marrow (BM) adipogenesis and the development and progression of hematologic malignancies. Recent Findings BM adipocytes (BMAds) support a number of processes promoting oncogenesis, including the evolution of clonal hematopoiesis, malignant cell survival, proliferation, angiogenesis, and chemoresistance. In addition, leukemic cells manipulate surrounding BMAds by promoting lipolysis and release of free fatty acids, which are then utilized by leu- kemic cells via β-oxidation. Therefore, limiting BM adipogenesis, blocking BMAd-derived adipokines, or lipid metabolism obstruction have been considered as potential treatment options for hematological malignancies. Summary Leukemic stem cells rely heavily on BMAds within the structural BM microenvironment for necessary signals which foster disease progression. Further development of 3D constructs resembling BMAT at different skeletal regions are critical to better understand these relationships in geometric space and may provide essential insight into the development of hematologic malignancies within the BM niche. In turn, these mechanisms provide promising potential as novel approaches to targeting the microenvironment with new therapeutic strategies.", publisher = "Springer Nature", journal = "Current Osteoporosis Reports", title = "Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development", doi = "10.1007/s11914-024-00879-x" }
Trivanović, D., Vujačić, M., Labella, R., Okić Đorđević, I., Ćazić, M., Chernak, B.,& Jauković, A.. (2024). Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development. in Current Osteoporosis Reports Springer Nature.. https://doi.org/10.1007/s11914-024-00879-x
Trivanović D, Vujačić M, Labella R, Okić Đorđević I, Ćazić M, Chernak B, Jauković A. Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development. in Current Osteoporosis Reports. 2024;. doi:10.1007/s11914-024-00879-x .
Trivanović, Drenka, Vujačić, Marko, Labella, Rossella, Okić Đorđević, Ivana, Ćazić, Marija, Chernak, Brian, Jauković, Aleksandra, "Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development" in Current Osteoporosis Reports (2024), https://doi.org/10.1007/s11914-024-00879-x . .