P1: Black currants and cornelian cherry juices prevent body characteristics and plasma lipid disturbance in high-fat high-fructose fed rats
Authors
Paunović, Marija![](/themes/MirageRIMI/images/orcid.png)
Vučić, Vesna
![](/themes/MirageRIMI/images/orcid.png)
Milošević, Maja
![](/themes/MirageRIMI/images/orcid.png)
Todorović, Vanja
Ristić-Medić, Danijela
![](/themes/MirageRIMI/images/orcid.png)
Arsić, Aleksandra
![](/themes/MirageRIMI/images/orcid.png)
Kojadinović, Milica
![](/themes/MirageRIMI/images/orcid.png)
Petrović, Snježana
![](/themes/MirageRIMI/images/orcid.png)
Conference object (Published version)
Metadata
Show full item recordAbstract
Metabolic syndrome (MetS) is a cluster of conditions- visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure -that increases the risk of cardiovascular disease and type 2 diabetes. Polyphenols from natural sources have an ameliorating effect on obesity-related metabolic disorders, and cardiovascular disease. This study was aimed to test the effects of polyphenol rich black currants (Ribes nigrum) and cornelian cherry (Cornus mas) juices on the body characteristics and plasma biochemistry parameters associated with MetS development in high-fat high-fructose (HFHF) fed rats. Male 4-month-old Wistar rats were divided into four groups (n=8): Control fed with standard chow diet +drinking water; HFHF fed with HFHF diet (standard chow diet with 25% sunflower oil, 20% fructose, 1% cholic acid) +drinking water; BC-HFHF fed with HFHF diet +25% black currants juice in drinking water; CC-HFHF fed with HFHF diet +25% cornelian cherry juice in drinking wa...ter. After 10 weeks of the dietary treatment, an increase of body fat (27,89±5,76 vs 14,97±2,85g), systolic (153,57±11 vs 128,33±12 mmHg) and diastolic (117,25±12 vs 100±12 mmHg) blood pressure, plasma glucose (6,36 ±0,72 vs 5,26 ±0,28 mmol/l), total (1,65±0,13 vs 1,41±0.10 mmol/l) and LDL-cholesterol (0,45±0,15 vs 0,24±0,16 mmol/l), and triglycerides (0,80±0,14 vs 0,64±0,12 mmol/l) was detected in HFHF group in comparison with Control, while HDLcholesterol was decreased (0,71±0,09 vs 0,97±0,14 mmol/l). Parallel treatment with black currants juice resulted in reduced body (391±35 vs 42±20g), fat (20,46±3,88 vs 14,97±2,85g) and liver mass (9,06±0,72 vs 10,23±1,29g), as well as in decreased glucose level (5,20±0,43 vs 6,36±0,72 mmol/l), total cholesterol (1,13±0,18 vs 1,65±0,13 mmol/l), triglycerides (0,51±0,21 vs 0,80±0,14 mmol/l) and liver enzymes AST (99,15±19 vs 193,68±70 IU/l) and ALT (35,20±3,5 vs 53,23±14 IU/l) in BC-HFHF when compared to HFHF group. Similarly, the lower total cholesterol (1,30±0,14 vs 1,65±0,13 mmol/l), triglycerides (0,58±0,16 vs 0,80±0,14 mmol/l), AST (110,30±60 vs 193,68±70 IU/l) and systolic blood pressure (141,17±9 vs 153,57±11 mmHg) were observed in CC-HFHF when compared with HFHF group. Obtained results have shown that polyphenol rich black currants and cornelian cherry juices have beneficial effect on the prevention of body characteristics and plasma biochemistry, particularly plasma lipid disturbance during dietary-induced MetS development.
Keywords:
Metabolic syndrome / high-fat high-fructose diet / black currants and cornelian cherry juice / plasma lipidSource:
3rd EpiLipidNET Action Meeting and The Young Researchers and Innovators Workshop, 21-23 September 2022, Aveiro, Portugal, 2022Publisher:
- Aveiro, Portugal : University of Aveiro
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
- CA19105 - Pan-European Network in Lipidomics and EpiLipidomics (EpiLipidNET)
Collections
Institution/Community
Institut za medicinska istraživanjaTY - CONF AU - Paunović, Marija AU - Vučić, Vesna AU - Milošević, Maja AU - Todorović, Vanja AU - Ristić-Medić, Danijela AU - Arsić, Aleksandra AU - Kojadinović, Milica AU - Petrović, Snježana PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1495 AB - Metabolic syndrome (MetS) is a cluster of conditions- visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure -that increases the risk of cardiovascular disease and type 2 diabetes. Polyphenols from natural sources have an ameliorating effect on obesity-related metabolic disorders, and cardiovascular disease. This study was aimed to test the effects of polyphenol rich black currants (Ribes nigrum) and cornelian cherry (Cornus mas) juices on the body characteristics and plasma biochemistry parameters associated with MetS development in high-fat high-fructose (HFHF) fed rats. Male 4-month-old Wistar rats were divided into four groups (n=8): Control fed with standard chow diet +drinking water; HFHF fed with HFHF diet (standard chow diet with 25% sunflower oil, 20% fructose, 1% cholic acid) +drinking water; BC-HFHF fed with HFHF diet +25% black currants juice in drinking water; CC-HFHF fed with HFHF diet +25% cornelian cherry juice in drinking water. After 10 weeks of the dietary treatment, an increase of body fat (27,89±5,76 vs 14,97±2,85g), systolic (153,57±11 vs 128,33±12 mmHg) and diastolic (117,25±12 vs 100±12 mmHg) blood pressure, plasma glucose (6,36 ±0,72 vs 5,26 ±0,28 mmol/l), total (1,65±0,13 vs 1,41±0.10 mmol/l) and LDL-cholesterol (0,45±0,15 vs 0,24±0,16 mmol/l), and triglycerides (0,80±0,14 vs 0,64±0,12 mmol/l) was detected in HFHF group in comparison with Control, while HDLcholesterol was decreased (0,71±0,09 vs 0,97±0,14 mmol/l). Parallel treatment with black currants juice resulted in reduced body (391±35 vs 42±20g), fat (20,46±3,88 vs 14,97±2,85g) and liver mass (9,06±0,72 vs 10,23±1,29g), as well as in decreased glucose level (5,20±0,43 vs 6,36±0,72 mmol/l), total cholesterol (1,13±0,18 vs 1,65±0,13 mmol/l), triglycerides (0,51±0,21 vs 0,80±0,14 mmol/l) and liver enzymes AST (99,15±19 vs 193,68±70 IU/l) and ALT (35,20±3,5 vs 53,23±14 IU/l) in BC-HFHF when compared to HFHF group. Similarly, the lower total cholesterol (1,30±0,14 vs 1,65±0,13 mmol/l), triglycerides (0,58±0,16 vs 0,80±0,14 mmol/l), AST (110,30±60 vs 193,68±70 IU/l) and systolic blood pressure (141,17±9 vs 153,57±11 mmHg) were observed in CC-HFHF when compared with HFHF group. Obtained results have shown that polyphenol rich black currants and cornelian cherry juices have beneficial effect on the prevention of body characteristics and plasma biochemistry, particularly plasma lipid disturbance during dietary-induced MetS development. PB - Aveiro, Portugal : University of Aveiro C3 - 3rd EpiLipidNET Action Meeting and The Young Researchers and Innovators Workshop, 21-23 September 2022, Aveiro, Portugal T1 - P1: Black currants and cornelian cherry juices prevent body characteristics and plasma lipid disturbance in high-fat high-fructose fed rats UR - https://hdl.handle.net/21.15107/rcub_rimi_1495 ER -
@conference{ author = "Paunović, Marija and Vučić, Vesna and Milošević, Maja and Todorović, Vanja and Ristić-Medić, Danijela and Arsić, Aleksandra and Kojadinović, Milica and Petrović, Snježana", year = "2022", abstract = "Metabolic syndrome (MetS) is a cluster of conditions- visceral obesity, high fasting glucose, high triglyceride, low HDL-cholesterol, high blood pressure -that increases the risk of cardiovascular disease and type 2 diabetes. Polyphenols from natural sources have an ameliorating effect on obesity-related metabolic disorders, and cardiovascular disease. This study was aimed to test the effects of polyphenol rich black currants (Ribes nigrum) and cornelian cherry (Cornus mas) juices on the body characteristics and plasma biochemistry parameters associated with MetS development in high-fat high-fructose (HFHF) fed rats. Male 4-month-old Wistar rats were divided into four groups (n=8): Control fed with standard chow diet +drinking water; HFHF fed with HFHF diet (standard chow diet with 25% sunflower oil, 20% fructose, 1% cholic acid) +drinking water; BC-HFHF fed with HFHF diet +25% black currants juice in drinking water; CC-HFHF fed with HFHF diet +25% cornelian cherry juice in drinking water. After 10 weeks of the dietary treatment, an increase of body fat (27,89±5,76 vs 14,97±2,85g), systolic (153,57±11 vs 128,33±12 mmHg) and diastolic (117,25±12 vs 100±12 mmHg) blood pressure, plasma glucose (6,36 ±0,72 vs 5,26 ±0,28 mmol/l), total (1,65±0,13 vs 1,41±0.10 mmol/l) and LDL-cholesterol (0,45±0,15 vs 0,24±0,16 mmol/l), and triglycerides (0,80±0,14 vs 0,64±0,12 mmol/l) was detected in HFHF group in comparison with Control, while HDLcholesterol was decreased (0,71±0,09 vs 0,97±0,14 mmol/l). Parallel treatment with black currants juice resulted in reduced body (391±35 vs 42±20g), fat (20,46±3,88 vs 14,97±2,85g) and liver mass (9,06±0,72 vs 10,23±1,29g), as well as in decreased glucose level (5,20±0,43 vs 6,36±0,72 mmol/l), total cholesterol (1,13±0,18 vs 1,65±0,13 mmol/l), triglycerides (0,51±0,21 vs 0,80±0,14 mmol/l) and liver enzymes AST (99,15±19 vs 193,68±70 IU/l) and ALT (35,20±3,5 vs 53,23±14 IU/l) in BC-HFHF when compared to HFHF group. Similarly, the lower total cholesterol (1,30±0,14 vs 1,65±0,13 mmol/l), triglycerides (0,58±0,16 vs 0,80±0,14 mmol/l), AST (110,30±60 vs 193,68±70 IU/l) and systolic blood pressure (141,17±9 vs 153,57±11 mmHg) were observed in CC-HFHF when compared with HFHF group. Obtained results have shown that polyphenol rich black currants and cornelian cherry juices have beneficial effect on the prevention of body characteristics and plasma biochemistry, particularly plasma lipid disturbance during dietary-induced MetS development.", publisher = "Aveiro, Portugal : University of Aveiro", journal = "3rd EpiLipidNET Action Meeting and The Young Researchers and Innovators Workshop, 21-23 September 2022, Aveiro, Portugal", title = "P1: Black currants and cornelian cherry juices prevent body characteristics and plasma lipid disturbance in high-fat high-fructose fed rats", url = "https://hdl.handle.net/21.15107/rcub_rimi_1495" }
Paunović, M., Vučić, V., Milošević, M., Todorović, V., Ristić-Medić, D., Arsić, A., Kojadinović, M.,& Petrović, S.. (2022). P1: Black currants and cornelian cherry juices prevent body characteristics and plasma lipid disturbance in high-fat high-fructose fed rats. in 3rd EpiLipidNET Action Meeting and The Young Researchers and Innovators Workshop, 21-23 September 2022, Aveiro, Portugal Aveiro, Portugal : University of Aveiro.. https://hdl.handle.net/21.15107/rcub_rimi_1495
Paunović M, Vučić V, Milošević M, Todorović V, Ristić-Medić D, Arsić A, Kojadinović M, Petrović S. P1: Black currants and cornelian cherry juices prevent body characteristics and plasma lipid disturbance in high-fat high-fructose fed rats. in 3rd EpiLipidNET Action Meeting and The Young Researchers and Innovators Workshop, 21-23 September 2022, Aveiro, Portugal. 2022;. https://hdl.handle.net/21.15107/rcub_rimi_1495 .
Paunović, Marija, Vučić, Vesna, Milošević, Maja, Todorović, Vanja, Ristić-Medić, Danijela, Arsić, Aleksandra, Kojadinović, Milica, Petrović, Snježana, "P1: Black currants and cornelian cherry juices prevent body characteristics and plasma lipid disturbance in high-fat high-fructose fed rats" in 3rd EpiLipidNET Action Meeting and The Young Researchers and Innovators Workshop, 21-23 September 2022, Aveiro, Portugal (2022), https://hdl.handle.net/21.15107/rcub_rimi_1495 .