An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis
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2024
Authors
Jain, AbhinavDe, Soumik
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Saraswat, Pranjal
Haribabu, Jebiti
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Santibanez, Juan F.
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Barman, Pranjit
Article (Published version)
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Designing economical and sensitive chemosensors for detecting important metal ions, like Cu2+ ions, is essential and remains a hot topic worldwide. In this investigation, we extended our investigation to design a specific diphenyl-azine-based skeletal system for the selective and sensitive detection of Cu2+ions. We reported a coumarin-diphenyl-azine-based AIEgen (C-1) using an improvised methodology with a large Stoke's shift (∼245 nm) for precisely sensing copper ions in solid, solution, and biological cells. The AIE-ESIPT properties of C-1 were validated using various sophisticated techniques. C-1 was found to be a promising selective and sensitive sensor of Cu2+ ions (nanomolar LOD value ∼10.38 nM) via colorimetric and TURNOFF fluorometric ways. The practical applicability of C-1 was analyzed via real-time estimation of copper ions in water samples (obtained from three varied locations) and in biological samples (urine and serum). The satisfactory recovery with a low RSD value indic...ates the potential of C-1 in detecting copper ions in actual samples. Estimating copper ions in urine and blood samples demonstrates the usefulness of C-1 in diagnosing disorders like Wilson's disease, which is caused by high concentrations of copper ions in the body. Additionally, we have detected Cu2+ions in live cells (HeLa cells) and carried out Latent Fingerprinting (Level 1 and Level 2) to validate its versatility in physiological and forensic applications. Overall, the proposed C-1 AIEgen is an ultrasensitive Cu2+ions sensor with innumerable applications in the physical world.
Keywords:
AIE-ESIPT / Cu2+sensing / Nanomolar detection / Real-sample analysis / Bioimaging / Latent fingerprintingSource:
Journal of Molecular Structure, 2024, 1310, 138383-Publisher:
- Elsevier
DOI: 10.1016/j.molstruc.2024.138383
ISSN: 0022-2860
WoS: 001232159600001
Scopus: 2-s2.0-85190728319
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Institut za medicinska istraživanjaTY - JOUR AU - Jain, Abhinav AU - De, Soumik AU - Saraswat, Pranjal AU - Haribabu, Jebiti AU - Santibanez, Juan F. AU - Barman, Pranjit PY - 2024 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1485 AB - Designing economical and sensitive chemosensors for detecting important metal ions, like Cu2+ ions, is essential and remains a hot topic worldwide. In this investigation, we extended our investigation to design a specific diphenyl-azine-based skeletal system for the selective and sensitive detection of Cu2+ions. We reported a coumarin-diphenyl-azine-based AIEgen (C-1) using an improvised methodology with a large Stoke's shift (∼245 nm) for precisely sensing copper ions in solid, solution, and biological cells. The AIE-ESIPT properties of C-1 were validated using various sophisticated techniques. C-1 was found to be a promising selective and sensitive sensor of Cu2+ ions (nanomolar LOD value ∼10.38 nM) via colorimetric and TURNOFF fluorometric ways. The practical applicability of C-1 was analyzed via real-time estimation of copper ions in water samples (obtained from three varied locations) and in biological samples (urine and serum). The satisfactory recovery with a low RSD value indicates the potential of C-1 in detecting copper ions in actual samples. Estimating copper ions in urine and blood samples demonstrates the usefulness of C-1 in diagnosing disorders like Wilson's disease, which is caused by high concentrations of copper ions in the body. Additionally, we have detected Cu2+ions in live cells (HeLa cells) and carried out Latent Fingerprinting (Level 1 and Level 2) to validate its versatility in physiological and forensic applications. Overall, the proposed C-1 AIEgen is an ultrasensitive Cu2+ions sensor with innumerable applications in the physical world. PB - Elsevier T2 - Journal of Molecular Structure T1 - An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis SP - 138383 SP - 138383 VL - 1310 DO - 10.1016/j.molstruc.2024.138383 ER -
@article{ author = "Jain, Abhinav and De, Soumik and Saraswat, Pranjal and Haribabu, Jebiti and Santibanez, Juan F. and Barman, Pranjit", year = "2024", abstract = "Designing economical and sensitive chemosensors for detecting important metal ions, like Cu2+ ions, is essential and remains a hot topic worldwide. In this investigation, we extended our investigation to design a specific diphenyl-azine-based skeletal system for the selective and sensitive detection of Cu2+ions. We reported a coumarin-diphenyl-azine-based AIEgen (C-1) using an improvised methodology with a large Stoke's shift (∼245 nm) for precisely sensing copper ions in solid, solution, and biological cells. The AIE-ESIPT properties of C-1 were validated using various sophisticated techniques. C-1 was found to be a promising selective and sensitive sensor of Cu2+ ions (nanomolar LOD value ∼10.38 nM) via colorimetric and TURNOFF fluorometric ways. The practical applicability of C-1 was analyzed via real-time estimation of copper ions in water samples (obtained from three varied locations) and in biological samples (urine and serum). The satisfactory recovery with a low RSD value indicates the potential of C-1 in detecting copper ions in actual samples. Estimating copper ions in urine and blood samples demonstrates the usefulness of C-1 in diagnosing disorders like Wilson's disease, which is caused by high concentrations of copper ions in the body. Additionally, we have detected Cu2+ions in live cells (HeLa cells) and carried out Latent Fingerprinting (Level 1 and Level 2) to validate its versatility in physiological and forensic applications. Overall, the proposed C-1 AIEgen is an ultrasensitive Cu2+ions sensor with innumerable applications in the physical world.", publisher = "Elsevier", journal = "Journal of Molecular Structure", title = "An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis", pages = "138383-138383", volume = "1310", doi = "10.1016/j.molstruc.2024.138383" }
Jain, A., De, S., Saraswat, P., Haribabu, J., Santibanez, J. F.,& Barman, P.. (2024). An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis. in Journal of Molecular Structure Elsevier., 1310, 138383. https://doi.org/10.1016/j.molstruc.2024.138383
Jain A, De S, Saraswat P, Haribabu J, Santibanez JF, Barman P. An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis. in Journal of Molecular Structure. 2024;1310:138383. doi:10.1016/j.molstruc.2024.138383 .
Jain, Abhinav, De, Soumik, Saraswat, Pranjal, Haribabu, Jebiti, Santibanez, Juan F., Barman, Pranjit, "An ESIPT active coumarin-diphenyl azine-based AIEgen: Nanomolar Cu2+ ion sensing, Latent Fingerprinting, live-cell imaging, and real sample analysis" in Journal of Molecular Structure, 1310 (2024):138383, https://doi.org/10.1016/j.molstruc.2024.138383 . .