8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression
Authors
Lačković, MajaStojković, Tihomir
Pantović Stefanović, Maja
Velimirović Bogosavljević, Milica
Nikolić, Tatjana
Tomanić, Milena
Nestorović, Milica
Debeljak-Martačić, Jasmina
Petronijević, Nataša
Article (Published version)
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Objective: Previous studies have shown that the disturbance of redox homeostasis plays a role in the pathogenesis of mood disorders. It is currently unclear whether oxidative stress parameters can be used as biomarkers (state vs. trait). The aim of the present study was to investigate oxidative stress markers in patients with major depressive disorder (MDD) and bipolar disorder (BP) in acute depressive episodes and remission, and healthy individuals. Patients and methods: Thirty-two patients with a diagnosis of MDD, 32 patients with a diagnosis of BP and 32 matched healthy controls were included in the study. We measured the serum levels of markers of oxidative damage, including 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-Iso-prostaglandin F2α (8-iso-PGF2α; 8-isoprostane), and malondialdehyde (MDA), and also serum activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR) in both acute and remission phase, and in control group. ...Results: After controlling for the effects of age, sex, body mass index, and smoking status, serum 8-iso-PGF2α levels were significantly higher in both patient groups compared to controls, regardless of disease phase. The activities of GPX and GR were significantly lower in the acute phase in MDD patients compared to controls. Serum GR activity was lower in both acute and remission phase in MDD compared to BP. Conclusions: Our results suggest that both MDD and BP are associated with a disturbed redox balance with a particularly pronounced increase in serum 8-iso-PGF2α levels in both groups and the presence of glutathione metabolism disorders in MDD patients. Further research is needed to confirm the importance of oxidative stress parameters as potential biomarkers of MDD and BP.
Keywords:
Oxidative Stress / Depression / Bipolar depression / Glutathione / 8-Iso-PGF2αSource:
European Review for Medical and Pharmacological Sciences, 2023, 27, 23, 11496-11507Publisher:
- Verduci Editore srl
Funding / projects:
- Structural and biochemical characteristics of synaptic plasticity alterations in psychiatric disorders (RS-MESTD-Basic Research (BR or ON)-175058)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-MESTD-inst-2020-200015)
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Institut za medicinska istraživanjaTY - JOUR AU - Lačković, Maja AU - Stojković, Tihomir AU - Pantović Stefanović, Maja AU - Velimirović Bogosavljević, Milica AU - Nikolić, Tatjana AU - Tomanić, Milena AU - Nestorović, Milica AU - Debeljak-Martačić, Jasmina AU - Petronijević, Nataša PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1388 AB - Objective: Previous studies have shown that the disturbance of redox homeostasis plays a role in the pathogenesis of mood disorders. It is currently unclear whether oxidative stress parameters can be used as biomarkers (state vs. trait). The aim of the present study was to investigate oxidative stress markers in patients with major depressive disorder (MDD) and bipolar disorder (BP) in acute depressive episodes and remission, and healthy individuals. Patients and methods: Thirty-two patients with a diagnosis of MDD, 32 patients with a diagnosis of BP and 32 matched healthy controls were included in the study. We measured the serum levels of markers of oxidative damage, including 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-Iso-prostaglandin F2α (8-iso-PGF2α; 8-isoprostane), and malondialdehyde (MDA), and also serum activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR) in both acute and remission phase, and in control group. Results: After controlling for the effects of age, sex, body mass index, and smoking status, serum 8-iso-PGF2α levels were significantly higher in both patient groups compared to controls, regardless of disease phase. The activities of GPX and GR were significantly lower in the acute phase in MDD patients compared to controls. Serum GR activity was lower in both acute and remission phase in MDD compared to BP. Conclusions: Our results suggest that both MDD and BP are associated with a disturbed redox balance with a particularly pronounced increase in serum 8-iso-PGF2α levels in both groups and the presence of glutathione metabolism disorders in MDD patients. Further research is needed to confirm the importance of oxidative stress parameters as potential biomarkers of MDD and BP. PB - Verduci Editore srl T2 - European Review for Medical and Pharmacological Sciences T1 - 8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression EP - 11507 EP - 11507 IS - 23 SP - 11496 SP - 11496 VL - 27 DO - 10.26355/eurrev_202312_34588 ER -
@article{ author = "Lačković, Maja and Stojković, Tihomir and Pantović Stefanović, Maja and Velimirović Bogosavljević, Milica and Nikolić, Tatjana and Tomanić, Milena and Nestorović, Milica and Debeljak-Martačić, Jasmina and Petronijević, Nataša", year = "2023", abstract = "Objective: Previous studies have shown that the disturbance of redox homeostasis plays a role in the pathogenesis of mood disorders. It is currently unclear whether oxidative stress parameters can be used as biomarkers (state vs. trait). The aim of the present study was to investigate oxidative stress markers in patients with major depressive disorder (MDD) and bipolar disorder (BP) in acute depressive episodes and remission, and healthy individuals. Patients and methods: Thirty-two patients with a diagnosis of MDD, 32 patients with a diagnosis of BP and 32 matched healthy controls were included in the study. We measured the serum levels of markers of oxidative damage, including 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-Iso-prostaglandin F2α (8-iso-PGF2α; 8-isoprostane), and malondialdehyde (MDA), and also serum activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR) in both acute and remission phase, and in control group. Results: After controlling for the effects of age, sex, body mass index, and smoking status, serum 8-iso-PGF2α levels were significantly higher in both patient groups compared to controls, regardless of disease phase. The activities of GPX and GR were significantly lower in the acute phase in MDD patients compared to controls. Serum GR activity was lower in both acute and remission phase in MDD compared to BP. Conclusions: Our results suggest that both MDD and BP are associated with a disturbed redox balance with a particularly pronounced increase in serum 8-iso-PGF2α levels in both groups and the presence of glutathione metabolism disorders in MDD patients. Further research is needed to confirm the importance of oxidative stress parameters as potential biomarkers of MDD and BP.", publisher = "Verduci Editore srl", journal = "European Review for Medical and Pharmacological Sciences", title = "8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression", pages = "11507-11507-11496-11496", number = "23", volume = "27", doi = "10.26355/eurrev_202312_34588" }
Lačković, M., Stojković, T., Pantović Stefanović, M., Velimirović Bogosavljević, M., Nikolić, T., Tomanić, M., Nestorović, M., Debeljak-Martačić, J.,& Petronijević, N.. (2023). 8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression. in European Review for Medical and Pharmacological Sciences Verduci Editore srl., 27(23), 11496-11507. https://doi.org/10.26355/eurrev_202312_34588
Lačković M, Stojković T, Pantović Stefanović M, Velimirović Bogosavljević M, Nikolić T, Tomanić M, Nestorović M, Debeljak-Martačić J, Petronijević N. 8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression. in European Review for Medical and Pharmacological Sciences. 2023;27(23):11496-11507. doi:10.26355/eurrev_202312_34588 .
Lačković, Maja, Stojković, Tihomir, Pantović Stefanović, Maja, Velimirović Bogosavljević, Milica, Nikolić, Tatjana, Tomanić, Milena, Nestorović, Milica, Debeljak-Martačić, Jasmina, Petronijević, Nataša, "8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression" in European Review for Medical and Pharmacological Sciences, 27, no. 23 (2023):11496-11507, https://doi.org/10.26355/eurrev_202312_34588 . .