Interplay between stress and cancer—A focus on inflammation
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Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be either a contributing or an aggravating factor for many chronic diseases including cancer. Chronic psychological stress has been identified as a significant factor contributing to the development and progression of cancer, but the mechanisms that link chronic stress to cancer remain incompletely understood. Psychological stressors initiate multiple physiological responses that result in the activation of the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system, and the subsequent changes in immune function. Chronic stress exposure disrupts the homeostatic communication between the neuroendocrine and immune systems, shifting immune signaling toward a proinflammatory state. Stress-induced chronic low-grade inflammation and a decline in immune surveillance a...re both implicated in cancer development and progression. Conversely, tumor-induced inflammatory cytokines, apart from driving a tumor-supportive inflammatory microenvironment, can also exert their biological actions distantly via circulation and therefore adversely affect the stress response. In this minireview, we summarize the current findings on the relationship between stress and cancer, focusing on the role of inflammation in stress-induced neuroendocrine-immune crosstalk. We also discuss the underlying mechanisms and their potential for cancer treatment and prevention.
Кључне речи:
chronic stress / cancer / inflammation / proinflammatory cytokines / microenvironmentИзвор:
Frontiers in Physiology, 2023, 14, 1119095-Издавач:
- Frontiers Media S.A.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Vignjević-Petrinović, Sanja AU - Milošević, Maja AU - Marković, Dragana AU - Momčilović, Sanja PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1300 AB - Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be either a contributing or an aggravating factor for many chronic diseases including cancer. Chronic psychological stress has been identified as a significant factor contributing to the development and progression of cancer, but the mechanisms that link chronic stress to cancer remain incompletely understood. Psychological stressors initiate multiple physiological responses that result in the activation of the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system, and the subsequent changes in immune function. Chronic stress exposure disrupts the homeostatic communication between the neuroendocrine and immune systems, shifting immune signaling toward a proinflammatory state. Stress-induced chronic low-grade inflammation and a decline in immune surveillance are both implicated in cancer development and progression. Conversely, tumor-induced inflammatory cytokines, apart from driving a tumor-supportive inflammatory microenvironment, can also exert their biological actions distantly via circulation and therefore adversely affect the stress response. In this minireview, we summarize the current findings on the relationship between stress and cancer, focusing on the role of inflammation in stress-induced neuroendocrine-immune crosstalk. We also discuss the underlying mechanisms and their potential for cancer treatment and prevention. PB - Frontiers Media S.A. T2 - Frontiers in Physiology T1 - Interplay between stress and cancer—A focus on inflammation SP - 1119095 VL - 14 DO - 10.3389/fphys.2023.1119095 ER -
@article{ author = "Vignjević-Petrinović, Sanja and Milošević, Maja and Marković, Dragana and Momčilović, Sanja", year = "2023", abstract = "Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be either a contributing or an aggravating factor for many chronic diseases including cancer. Chronic psychological stress has been identified as a significant factor contributing to the development and progression of cancer, but the mechanisms that link chronic stress to cancer remain incompletely understood. Psychological stressors initiate multiple physiological responses that result in the activation of the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system, and the subsequent changes in immune function. Chronic stress exposure disrupts the homeostatic communication between the neuroendocrine and immune systems, shifting immune signaling toward a proinflammatory state. Stress-induced chronic low-grade inflammation and a decline in immune surveillance are both implicated in cancer development and progression. Conversely, tumor-induced inflammatory cytokines, apart from driving a tumor-supportive inflammatory microenvironment, can also exert their biological actions distantly via circulation and therefore adversely affect the stress response. In this minireview, we summarize the current findings on the relationship between stress and cancer, focusing on the role of inflammation in stress-induced neuroendocrine-immune crosstalk. We also discuss the underlying mechanisms and their potential for cancer treatment and prevention.", publisher = "Frontiers Media S.A.", journal = "Frontiers in Physiology", title = "Interplay between stress and cancer—A focus on inflammation", pages = "1119095", volume = "14", doi = "10.3389/fphys.2023.1119095" }
Vignjević-Petrinović, S., Milošević, M., Marković, D.,& Momčilović, S.. (2023). Interplay between stress and cancer—A focus on inflammation. in Frontiers in Physiology Frontiers Media S.A.., 14, 1119095. https://doi.org/10.3389/fphys.2023.1119095
Vignjević-Petrinović S, Milošević M, Marković D, Momčilović S. Interplay between stress and cancer—A focus on inflammation. in Frontiers in Physiology. 2023;14:1119095. doi:10.3389/fphys.2023.1119095 .
Vignjević-Petrinović, Sanja, Milošević, Maja, Marković, Dragana, Momčilović, Sanja, "Interplay between stress and cancer—A focus on inflammation" in Frontiers in Physiology, 14 (2023):1119095, https://doi.org/10.3389/fphys.2023.1119095 . .