Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential
Autori
Drvenica, IvanaBlažević, Ivica
Bošković, Perica
Bratanić, Andre
Bugarski, Branko
Bilušić, Tea
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human digestive juices. The antioxidant potential of sinigrin and sinigrin-loaded liposomes was determined with the Rancimat test as their ability to prolong oxidative stability of edible oil. The efficiency of 62% was obtained by encapsulating sinigrin in liposomes. The values of mean diameter, polydispersity index and zeta potential showed satisfactory size uniformity and physical stability of the liposomes containing sinigrin. Liposomes were shown to inhibit the digestion of sinigrin in both human gastric and intestinal juices, clearly enabling its prolonged release. Moreover, sinigrin in the liposomal form significantly prolonged the induction time ...of edible oil oxidation compared to its free form. The results obtained are encouraging from the point of view of a possible incorporation of the sinigrin-loaded liposomes in real functional food systems or their use as nutraceuticals.
Ključne reči:
sinigrin / liposomes / oxidative stability / gastric digestion / duodenal digestion / antioxidant potentialIzvor:
Polish Journal of Food and Nutrition Sciences, 2021, 71, 4, 441-449Izdavač:
- Polish Academy Sciences. Institute of Animal Reproduction and Food Research
Finansiranje / projekti:
- Croatian Science Foundation -“Plants as a source of bioactive sulphur compounds and their ability to hyperracumulate metals” (IP-06-2016-1316)
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Drvenica, Ivana AU - Blažević, Ivica AU - Bošković, Perica AU - Bratanić, Andre AU - Bugarski, Branko AU - Bilušić, Tea PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1218 AB - Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human digestive juices. The antioxidant potential of sinigrin and sinigrin-loaded liposomes was determined with the Rancimat test as their ability to prolong oxidative stability of edible oil. The efficiency of 62% was obtained by encapsulating sinigrin in liposomes. The values of mean diameter, polydispersity index and zeta potential showed satisfactory size uniformity and physical stability of the liposomes containing sinigrin. Liposomes were shown to inhibit the digestion of sinigrin in both human gastric and intestinal juices, clearly enabling its prolonged release. Moreover, sinigrin in the liposomal form significantly prolonged the induction time of edible oil oxidation compared to its free form. The results obtained are encouraging from the point of view of a possible incorporation of the sinigrin-loaded liposomes in real functional food systems or their use as nutraceuticals. PB - Polish Academy Sciences. Institute of Animal Reproduction and Food Research T2 - Polish Journal of Food and Nutrition Sciences T1 - Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential EP - 449 IS - 4 SP - 441 VL - 71 DO - 10.31883/pjfns/143574 ER -
@article{ author = "Drvenica, Ivana and Blažević, Ivica and Bošković, Perica and Bratanić, Andre and Bugarski, Branko and Bilušić, Tea", year = "2021", abstract = "Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human digestive juices. The antioxidant potential of sinigrin and sinigrin-loaded liposomes was determined with the Rancimat test as their ability to prolong oxidative stability of edible oil. The efficiency of 62% was obtained by encapsulating sinigrin in liposomes. The values of mean diameter, polydispersity index and zeta potential showed satisfactory size uniformity and physical stability of the liposomes containing sinigrin. Liposomes were shown to inhibit the digestion of sinigrin in both human gastric and intestinal juices, clearly enabling its prolonged release. Moreover, sinigrin in the liposomal form significantly prolonged the induction time of edible oil oxidation compared to its free form. The results obtained are encouraging from the point of view of a possible incorporation of the sinigrin-loaded liposomes in real functional food systems or their use as nutraceuticals.", publisher = "Polish Academy Sciences. Institute of Animal Reproduction and Food Research", journal = "Polish Journal of Food and Nutrition Sciences", title = "Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential", pages = "449-441", number = "4", volume = "71", doi = "10.31883/pjfns/143574" }
Drvenica, I., Blažević, I., Bošković, P., Bratanić, A., Bugarski, B.,& Bilušić, T.. (2021). Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential. in Polish Journal of Food and Nutrition Sciences Polish Academy Sciences. Institute of Animal Reproduction and Food Research., 71(4), 441-449. https://doi.org/10.31883/pjfns/143574
Drvenica I, Blažević I, Bošković P, Bratanić A, Bugarski B, Bilušić T. Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential. in Polish Journal of Food and Nutrition Sciences. 2021;71(4):441-449. doi:10.31883/pjfns/143574 .
Drvenica, Ivana, Blažević, Ivica, Bošković, Perica, Bratanić, Andre, Bugarski, Branko, Bilušić, Tea, "Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential" in Polish Journal of Food and Nutrition Sciences, 71, no. 4 (2021):441-449, https://doi.org/10.31883/pjfns/143574 . .