The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor
Аутори
Bumbaširević, UrošBojanić, Nebojša
Plješa-Ercegovac, Marija S.
Živković, Marko
Đukić, Tatjana I.
Zeković, Milica
Milojević, Bogomir
Kajmaković, Boris
Janičić, Aleksandar
Simić, Tatjana
Ćorić, Vesna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The simultaneous analysis of redox biomarkers and polymorphisms encoding for regulatory and catalytic antioxidant proteins was performed in order to evaluate their potential role in the development of testicular germ cell tumor (GCT), as well as the progression of the disease. NRF2 (rs6721961), GSTM3 (rs1332018), SOD2 (rs4880) and GPX3 (rs8177412) polymorphisms were assessed in 88 patients with testicular GCT (52 with seminoma) and 88 age-matched controls. The plasma levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), thiol groups and the plasma activity of glutathione peroxidase were measured. A significant association between variant GPX3*TC+CC genotype and risk of overall testicular GCT, as well as seminoma development, was found. Moreover, carriers of variant SOD2*TT genotype were at almost 3-fold increased risk of seminoma development. Interestingly, combined SOD2*TT/GPX3*TC+CC genotype conferred a 7-fold higher risk for testicular GCT development. Finally, variant GSTM3*AC+CC genotyp...e was associated with a higher risk for the development of advanced diseased. The presence of assessed genetic variants was not associated with significantly higher levels of redox biomarkers in both testicular GCT patients, as well as in those diagnosed with seminoma. In conclusion, the polymorphic expression of certain antioxidant enzymes might affect susceptibility toward testicular GCT development, as well as the progression of the disease.
Кључне речи:
testicular GCT / oxidative stress / polymorphism / redox biomarkersИзвор:
Cancers, 2022, 14, 4, 1068-Издавач:
- Multidisciplinary Digital Publishing Institute (MDPI)
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Bumbaširević, Uroš AU - Bojanić, Nebojša AU - Plješa-Ercegovac, Marija S. AU - Živković, Marko AU - Đukić, Tatjana I. AU - Zeković, Milica AU - Milojević, Bogomir AU - Kajmaković, Boris AU - Janičić, Aleksandar AU - Simić, Tatjana AU - Ćorić, Vesna PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1209 AB - The simultaneous analysis of redox biomarkers and polymorphisms encoding for regulatory and catalytic antioxidant proteins was performed in order to evaluate their potential role in the development of testicular germ cell tumor (GCT), as well as the progression of the disease. NRF2 (rs6721961), GSTM3 (rs1332018), SOD2 (rs4880) and GPX3 (rs8177412) polymorphisms were assessed in 88 patients with testicular GCT (52 with seminoma) and 88 age-matched controls. The plasma levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), thiol groups and the plasma activity of glutathione peroxidase were measured. A significant association between variant GPX3*TC+CC genotype and risk of overall testicular GCT, as well as seminoma development, was found. Moreover, carriers of variant SOD2*TT genotype were at almost 3-fold increased risk of seminoma development. Interestingly, combined SOD2*TT/GPX3*TC+CC genotype conferred a 7-fold higher risk for testicular GCT development. Finally, variant GSTM3*AC+CC genotype was associated with a higher risk for the development of advanced diseased. The presence of assessed genetic variants was not associated with significantly higher levels of redox biomarkers in both testicular GCT patients, as well as in those diagnosed with seminoma. In conclusion, the polymorphic expression of certain antioxidant enzymes might affect susceptibility toward testicular GCT development, as well as the progression of the disease. PB - Multidisciplinary Digital Publishing Institute (MDPI) T2 - Cancers T1 - The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor IS - 4 SP - 1068 VL - 14 DO - 10.3390/cancers14041068 ER -
@article{ author = "Bumbaširević, Uroš and Bojanić, Nebojša and Plješa-Ercegovac, Marija S. and Živković, Marko and Đukić, Tatjana I. and Zeković, Milica and Milojević, Bogomir and Kajmaković, Boris and Janičić, Aleksandar and Simić, Tatjana and Ćorić, Vesna", year = "2022", abstract = "The simultaneous analysis of redox biomarkers and polymorphisms encoding for regulatory and catalytic antioxidant proteins was performed in order to evaluate their potential role in the development of testicular germ cell tumor (GCT), as well as the progression of the disease. NRF2 (rs6721961), GSTM3 (rs1332018), SOD2 (rs4880) and GPX3 (rs8177412) polymorphisms were assessed in 88 patients with testicular GCT (52 with seminoma) and 88 age-matched controls. The plasma levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), thiol groups and the plasma activity of glutathione peroxidase were measured. A significant association between variant GPX3*TC+CC genotype and risk of overall testicular GCT, as well as seminoma development, was found. Moreover, carriers of variant SOD2*TT genotype were at almost 3-fold increased risk of seminoma development. Interestingly, combined SOD2*TT/GPX3*TC+CC genotype conferred a 7-fold higher risk for testicular GCT development. Finally, variant GSTM3*AC+CC genotype was associated with a higher risk for the development of advanced diseased. The presence of assessed genetic variants was not associated with significantly higher levels of redox biomarkers in both testicular GCT patients, as well as in those diagnosed with seminoma. In conclusion, the polymorphic expression of certain antioxidant enzymes might affect susceptibility toward testicular GCT development, as well as the progression of the disease.", publisher = "Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Cancers", title = "The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor", number = "4", pages = "1068", volume = "14", doi = "10.3390/cancers14041068" }
Bumbaširević, U., Bojanić, N., Plješa-Ercegovac, M. S., Živković, M., Đukić, T. I., Zeković, M., Milojević, B., Kajmaković, B., Janičić, A., Simić, T.,& Ćorić, V.. (2022). The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor. in Cancers Multidisciplinary Digital Publishing Institute (MDPI)., 14(4), 1068. https://doi.org/10.3390/cancers14041068
Bumbaširević U, Bojanić N, Plješa-Ercegovac MS, Živković M, Đukić TI, Zeković M, Milojević B, Kajmaković B, Janičić A, Simić T, Ćorić V. The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor. in Cancers. 2022;14(4):1068. doi:10.3390/cancers14041068 .
Bumbaširević, Uroš, Bojanić, Nebojša, Plješa-Ercegovac, Marija S., Živković, Marko, Đukić, Tatjana I., Zeković, Milica, Milojević, Bogomir, Kajmaković, Boris, Janičić, Aleksandar, Simić, Tatjana, Ćorić, Vesna, "The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor" in Cancers, 14, no. 4 (2022):1068, https://doi.org/10.3390/cancers14041068 . .