Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats
Authors
Grujić-Milanović, JelicaMiloradović, Zoran
Mihailović-Stanojević, Nevena
Banjac, Vojislav V.
Vidosavljević, Strahinja
Ivanov, Milan
Karanović, Danijela
Vajić, Una Jovana
Jovović, Đurđica
Article (Published version)
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Show full item recordAbstract
Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage.
Keywords:
Dysfunctional HDL-C / High fat diet / IL-6 / Myeloperoxidase / Pentraxin-3 / Soybean oilSource:
Biomedicine & Pharmacotherapy, 2021, 139, 111691-Publisher:
- Elsevier
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)
- Serbia-Croatia Bilateral agreement (No. 337-00-205/2019-09/32)
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Institut za medicinska istraživanjaTY - JOUR AU - Grujić-Milanović, Jelica AU - Miloradović, Zoran AU - Mihailović-Stanojević, Nevena AU - Banjac, Vojislav V. AU - Vidosavljević, Strahinja AU - Ivanov, Milan AU - Karanović, Danijela AU - Vajić, Una Jovana AU - Jovović, Đurđica PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1132 AB - Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage. PB - Elsevier T2 - Biomedicine & Pharmacotherapy T1 - Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats SP - 111691 VL - 139 DO - 10.1016/j.biopha.2021.111691 ER -
@article{ author = "Grujić-Milanović, Jelica and Miloradović, Zoran and Mihailović-Stanojević, Nevena and Banjac, Vojislav V. and Vidosavljević, Strahinja and Ivanov, Milan and Karanović, Danijela and Vajić, Una Jovana and Jovović, Đurđica", year = "2021", abstract = "Lifestyle modifications such as increase in high-fat food consumption importantly increases the risks for cardiovascular disease. The principal objective of this study is to analyze effects of different high fat diet (HFD) sources on haemodynamic parameters, lipid and oxidative profile, myeloperoxidase activity, and markers of inflammation (IL-6/pentraxin-3). HFD containing 20% of fat, provided by lard (saturated) or soybean oil (unsaturated), as well as control diet were administering to three groups (L, SO and C). Food efficiency ratio and plasma lipids were significantly elevated in both HFD groups. However, only SO group showed an increase in systolic arterial pressure, oxidative stress index, myeloperoxidase activity, liver lipids as well as markers of inflammation: IL-6 and pentraxin-3 (PTX3). In summary, these results indicate inflammogenic potential of excessive soybean oil consumption in triggering liver damage.", publisher = "Elsevier", journal = "Biomedicine & Pharmacotherapy", title = "Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats", pages = "111691", volume = "139", doi = "10.1016/j.biopha.2021.111691" }
Grujić-Milanović, J., Miloradović, Z., Mihailović-Stanojević, N., Banjac, V. V., Vidosavljević, S., Ivanov, M., Karanović, D., Vajić, U. J.,& Jovović, Đ.. (2021). Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats. in Biomedicine & Pharmacotherapy Elsevier., 139, 111691. https://doi.org/10.1016/j.biopha.2021.111691
Grujić-Milanović J, Miloradović Z, Mihailović-Stanojević N, Banjac VV, Vidosavljević S, Ivanov M, Karanović D, Vajić UJ, Jovović Đ. Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats. in Biomedicine & Pharmacotherapy. 2021;139:111691. doi:10.1016/j.biopha.2021.111691 .
Grujić-Milanović, Jelica, Miloradović, Zoran, Mihailović-Stanojević, Nevena, Banjac, Vojislav V., Vidosavljević, Strahinja, Ivanov, Milan, Karanović, Danijela, Vajić, Una Jovana, Jovović, Đurđica, "Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats" in Biomedicine & Pharmacotherapy, 139 (2021):111691, https://doi.org/10.1016/j.biopha.2021.111691 . .