Adverse plasma fatty acid composition in patients with femoral neck fracture
Samo za registrovane korisnike
2020
Autori
Arsić, AleksandraPešić, Goran
Petrović, Snježana
Matić, Aleksandar
Jeremić, Jovana
Jakovljević, Vladimir
Vučić, Vesna M.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-alpha and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-alpha and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered... FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered.
Ključne reči:
femoral neck fracture / presurgery / postsurgery / fatty acid / arachidonic acid / TNF-alpha / IL-6 / thiobarbituric acid reactive substancesIzvor:
Canadian Journal of Physiology & Pharmacology, 2020, 98, 2, 61-66Izdavač:
- Canadian Science Publishing, Ottawa
Finansiranje / projekti:
- Biološki mehanizmi, nutritivni unos i status polinezasićenih masnih kiselina i folata: Unapređenje ishrane u Srbiji (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
DOI: 10.1139/cjpp-2019-0249
ISSN: 0008-4212
PubMed: 31491342
WoS: 000514076700003
Scopus: 2-s2.0-85079202868
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Arsić, Aleksandra AU - Pešić, Goran AU - Petrović, Snježana AU - Matić, Aleksandar AU - Jeremić, Jovana AU - Jakovljević, Vladimir AU - Vučić, Vesna M. PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1036 AB - Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-alpha and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-alpha and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered. PB - Canadian Science Publishing, Ottawa T2 - Canadian Journal of Physiology & Pharmacology T1 - Adverse plasma fatty acid composition in patients with femoral neck fracture EP - 66 IS - 2 SP - 61 VL - 98 DO - 10.1139/cjpp-2019-0249 ER -
@article{ author = "Arsić, Aleksandra and Pešić, Goran and Petrović, Snježana and Matić, Aleksandar and Jeremić, Jovana and Jakovljević, Vladimir and Vučić, Vesna M.", year = "2020", abstract = "Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-alpha and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-alpha and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered.", publisher = "Canadian Science Publishing, Ottawa", journal = "Canadian Journal of Physiology & Pharmacology", title = "Adverse plasma fatty acid composition in patients with femoral neck fracture", pages = "66-61", number = "2", volume = "98", doi = "10.1139/cjpp-2019-0249" }
Arsić, A., Pešić, G., Petrović, S., Matić, A., Jeremić, J., Jakovljević, V.,& Vučić, V. M.. (2020). Adverse plasma fatty acid composition in patients with femoral neck fracture. in Canadian Journal of Physiology & Pharmacology Canadian Science Publishing, Ottawa., 98(2), 61-66. https://doi.org/10.1139/cjpp-2019-0249
Arsić A, Pešić G, Petrović S, Matić A, Jeremić J, Jakovljević V, Vučić VM. Adverse plasma fatty acid composition in patients with femoral neck fracture. in Canadian Journal of Physiology & Pharmacology. 2020;98(2):61-66. doi:10.1139/cjpp-2019-0249 .
Arsić, Aleksandra, Pešić, Goran, Petrović, Snježana, Matić, Aleksandar, Jeremić, Jovana, Jakovljević, Vladimir, Vučić, Vesna M., "Adverse plasma fatty acid composition in patients with femoral neck fracture" in Canadian Journal of Physiology & Pharmacology, 98, no. 2 (2020):61-66, https://doi.org/10.1139/cjpp-2019-0249 . .