Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis
2017
Аутори
Veselinović, MirjanaVasiljević, Dragan
Vučić, Vesna M.
Arsić, Aleksandra
Petrović, Snježana
Tomic-Lucić, Aleksandra
Savić, Maja
Živanović, Sandra
Stojić, Vladislava
Jakovljević, Vladimir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
(1) Background: Marine n-3 polyunsaturated fatty acids (PUFA) and (sic)-linolenic acid (GLA) are well-known anti-inflammatory agents that may help in the treatment of inflammatory disorders. Their effects were examined in patients with rheumatoid arthritis; (2) Methods: Sixty patients with active rheumatoid arthritis were involved in a prospective, randomized trial of a 12 week supplementation with fish oil (group I), fish oil with primrose evening oil (group II), or with no supplementation (group III). Clinical and laboratory evaluations were done at the beginning and at the end of the study; (3) Results: The Disease Activity Score 28 (DAS 28 score), number of tender joints and visual analogue scale (VAS) score decreased notably after supplementation in groups I and II (p lt 0.001). In plasma phospholipids the n-6/n-3 fatty acids ratio declined from 15.47 +/- 5.51 to 10.62 +/- 5.07 (p = 0.005), and from 18.15 +/- 5.04 to 13.50 +/- 4.81 (p = 0.005) in groups I and II respectively. Th...e combination of n-3 PUFA and GLA (group II) increased.-linolenic acid (0.00 +/- 0.00 to 0.13 +/- 0.11, p lt 0.001), which was undetectable in all groups before the treatments; (4) Conclusion: Daily supplementation with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.
Кључне речи:
n-3 PUFA / ɤ linolenic acid / rheumatoid arthritisИзвор:
Nutrients, 2017, 9, 4, 325-Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- Ефекти хомоцистеина и хомоцистеину сродних супстанци на кардиоваскуларни систем: Улога гасних трансмитера No, H2S и CO (RS-MESTD-Basic Research (BR or ON)-175043)
DOI: 10.3390/nu9040325
ISSN: 2072-6643
PubMed: 28346333
WoS: 000401355600010
Scopus: 2-s2.0-85016258721
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Veselinović, Mirjana AU - Vasiljević, Dragan AU - Vučić, Vesna M. AU - Arsić, Aleksandra AU - Petrović, Snježana AU - Tomic-Lucić, Aleksandra AU - Savić, Maja AU - Živanović, Sandra AU - Stojić, Vladislava AU - Jakovljević, Vladimir PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/824 AB - (1) Background: Marine n-3 polyunsaturated fatty acids (PUFA) and (sic)-linolenic acid (GLA) are well-known anti-inflammatory agents that may help in the treatment of inflammatory disorders. Their effects were examined in patients with rheumatoid arthritis; (2) Methods: Sixty patients with active rheumatoid arthritis were involved in a prospective, randomized trial of a 12 week supplementation with fish oil (group I), fish oil with primrose evening oil (group II), or with no supplementation (group III). Clinical and laboratory evaluations were done at the beginning and at the end of the study; (3) Results: The Disease Activity Score 28 (DAS 28 score), number of tender joints and visual analogue scale (VAS) score decreased notably after supplementation in groups I and II (p lt 0.001). In plasma phospholipids the n-6/n-3 fatty acids ratio declined from 15.47 +/- 5.51 to 10.62 +/- 5.07 (p = 0.005), and from 18.15 +/- 5.04 to 13.50 +/- 4.81 (p = 0.005) in groups I and II respectively. The combination of n-3 PUFA and GLA (group II) increased.-linolenic acid (0.00 +/- 0.00 to 0.13 +/- 0.11, p lt 0.001), which was undetectable in all groups before the treatments; (4) Conclusion: Daily supplementation with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity. PB - MDPI, Basel T2 - Nutrients T1 - Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis IS - 4 SP - 325 VL - 9 DO - 10.3390/nu9040325 ER -
@article{ author = "Veselinović, Mirjana and Vasiljević, Dragan and Vučić, Vesna M. and Arsić, Aleksandra and Petrović, Snježana and Tomic-Lucić, Aleksandra and Savić, Maja and Živanović, Sandra and Stojić, Vladislava and Jakovljević, Vladimir", year = "2017", abstract = "(1) Background: Marine n-3 polyunsaturated fatty acids (PUFA) and (sic)-linolenic acid (GLA) are well-known anti-inflammatory agents that may help in the treatment of inflammatory disorders. Their effects were examined in patients with rheumatoid arthritis; (2) Methods: Sixty patients with active rheumatoid arthritis were involved in a prospective, randomized trial of a 12 week supplementation with fish oil (group I), fish oil with primrose evening oil (group II), or with no supplementation (group III). Clinical and laboratory evaluations were done at the beginning and at the end of the study; (3) Results: The Disease Activity Score 28 (DAS 28 score), number of tender joints and visual analogue scale (VAS) score decreased notably after supplementation in groups I and II (p lt 0.001). In plasma phospholipids the n-6/n-3 fatty acids ratio declined from 15.47 +/- 5.51 to 10.62 +/- 5.07 (p = 0.005), and from 18.15 +/- 5.04 to 13.50 +/- 4.81 (p = 0.005) in groups I and II respectively. The combination of n-3 PUFA and GLA (group II) increased.-linolenic acid (0.00 +/- 0.00 to 0.13 +/- 0.11, p lt 0.001), which was undetectable in all groups before the treatments; (4) Conclusion: Daily supplementation with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.", publisher = "MDPI, Basel", journal = "Nutrients", title = "Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis", number = "4", pages = "325", volume = "9", doi = "10.3390/nu9040325" }
Veselinović, M., Vasiljević, D., Vučić, V. M., Arsić, A., Petrović, S., Tomic-Lucić, A., Savić, M., Živanović, S., Stojić, V.,& Jakovljević, V.. (2017). Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. in Nutrients MDPI, Basel., 9(4), 325. https://doi.org/10.3390/nu9040325
Veselinović M, Vasiljević D, Vučić VM, Arsić A, Petrović S, Tomic-Lucić A, Savić M, Živanović S, Stojić V, Jakovljević V. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. in Nutrients. 2017;9(4):325. doi:10.3390/nu9040325 .
Veselinović, Mirjana, Vasiljević, Dragan, Vučić, Vesna M., Arsić, Aleksandra, Petrović, Snježana, Tomic-Lucić, Aleksandra, Savić, Maja, Živanović, Sandra, Stojić, Vladislava, Jakovljević, Vladimir, "Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis" in Nutrients, 9, no. 4 (2017):325, https://doi.org/10.3390/nu9040325 . .