The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status
Апстракт
Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-gamma-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.
Кључне речи:
biomarker / Zn / LA:DGLA / Zn status / fatty acidИзвор:
Nutrients, 2017, 9, 8, 825-Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Australian Postgraduate Award Scholarship
DOI: 10.3390/nu9080825
ISSN: 2072-6643
PubMed: 28763004
WoS: 000408688100032
Scopus: 2-s2.0-85026803505
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Knez, Marija AU - Stangoulis, James C. R. AU - Glibetić, Marija AU - Tako, Elad PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/764 AB - Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-gamma-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential. PB - MDPI, Basel T2 - Nutrients T1 - The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status IS - 8 SP - 825 VL - 9 DO - 10.3390/nu9080825 ER -
@article{ author = "Knez, Marija and Stangoulis, James C. R. and Glibetić, Marija and Tako, Elad", year = "2017", abstract = "Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-gamma-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.", publisher = "MDPI, Basel", journal = "Nutrients", title = "The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status", number = "8", pages = "825", volume = "9", doi = "10.3390/nu9080825" }
Knez, M., Stangoulis, J. C. R., Glibetić, M.,& Tako, E.. (2017). The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status. in Nutrients MDPI, Basel., 9(8), 825. https://doi.org/10.3390/nu9080825
Knez M, Stangoulis JCR, Glibetić M, Tako E. The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status. in Nutrients. 2017;9(8):825. doi:10.3390/nu9080825 .
Knez, Marija, Stangoulis, James C. R., Glibetić, Marija, Tako, Elad, "The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status" in Nutrients, 9, no. 8 (2017):825, https://doi.org/10.3390/nu9080825 . .