Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking
Само за регистроване кориснике
2016
Аутори
Radovanović, Saša M.Perić, Stojan
Savić-Pavićević, D.
Dobricić, V.
Pesović, J.
Kostić, Vladimir S.
Rakočević-Stojanović, V.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: We analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while performing dual mental and motor tasks, and investigated correlations between gait parameters and cognitive impairments. Method: Dual-task walking was performed by 37 patients (20 DM1 and 17 DM2) and 48 healthy subjects divided into two groups, age-and gender-matched control group for DM1 (HC1) and age-and gender-matched control group for DM2 (HC2). The subjects performed a basic walking task, dual-motor task, dual-mental task, and combined motor and mental task. Results: DM1 and DM2 patients differed significantly in temporal and stride characteristics compared to HC. Main differences in DM1 were slower gait and shorter stride length, while both DM1 and DM2 patients had a higher degree of variation of the swing time during dual-task gait, a parameter that reflects posture and balance. Impact of the cognitive dual task on gait pattern changes was also obser...ved. Visuospatial ability correlated with gait changes in DM1, while executive functions had stronger influence in DM2 (p lt 0.01). Both patient groups had leg muscle weakness. Conclusion: Gait pattern was impaired in both patient groups concerning temporal and stride characteristics. Dual-task walking paradigm may discover mild initial gait changes and could provide early identification of fall risks and predict possible falls in DM patients.
Кључне речи:
Myotonic dystrophy type 1 / Myotonic dystrophy type 2 / Cognitive task / GAITRite walkway system / Temporal and stride parametersИзвор:
Gait & Posture, 2016, 44, 194-199Издавач:
- Elsevier Ireland Ltd, Clare
Финансирање / пројекти:
- Моторни и немоторни симптоми паркинсонизма: клиничке, морфолошке и молекуларно-генетичке корелације (RS-MESTD-Basic Research (BR or ON)-175090)
- Испитивање молекуларно-генетских, патохистолошких и биохемијских карактеристика неуромишићних болести (RS-MESTD-Basic Research (BR or ON)-175083)
DOI: 10.1016/j.gaitpost.2015.12.020
ISSN: 0966-6362
PubMed: 27004657
WoS: 000372487000034
Scopus: 2-s2.0-84960928650
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Radovanović, Saša M. AU - Perić, Stojan AU - Savić-Pavićević, D. AU - Dobricić, V. AU - Pesović, J. AU - Kostić, Vladimir S. AU - Rakočević-Stojanović, V. PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/738 AB - Objective: We analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while performing dual mental and motor tasks, and investigated correlations between gait parameters and cognitive impairments. Method: Dual-task walking was performed by 37 patients (20 DM1 and 17 DM2) and 48 healthy subjects divided into two groups, age-and gender-matched control group for DM1 (HC1) and age-and gender-matched control group for DM2 (HC2). The subjects performed a basic walking task, dual-motor task, dual-mental task, and combined motor and mental task. Results: DM1 and DM2 patients differed significantly in temporal and stride characteristics compared to HC. Main differences in DM1 were slower gait and shorter stride length, while both DM1 and DM2 patients had a higher degree of variation of the swing time during dual-task gait, a parameter that reflects posture and balance. Impact of the cognitive dual task on gait pattern changes was also observed. Visuospatial ability correlated with gait changes in DM1, while executive functions had stronger influence in DM2 (p lt 0.01). Both patient groups had leg muscle weakness. Conclusion: Gait pattern was impaired in both patient groups concerning temporal and stride characteristics. Dual-task walking paradigm may discover mild initial gait changes and could provide early identification of fall risks and predict possible falls in DM patients. PB - Elsevier Ireland Ltd, Clare T2 - Gait & Posture T1 - Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking EP - 199 SP - 194 VL - 44 DO - 10.1016/j.gaitpost.2015.12.020 ER -
@article{ author = "Radovanović, Saša M. and Perić, Stojan and Savić-Pavićević, D. and Dobricić, V. and Pesović, J. and Kostić, Vladimir S. and Rakočević-Stojanović, V.", year = "2016", abstract = "Objective: We analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while performing dual mental and motor tasks, and investigated correlations between gait parameters and cognitive impairments. Method: Dual-task walking was performed by 37 patients (20 DM1 and 17 DM2) and 48 healthy subjects divided into two groups, age-and gender-matched control group for DM1 (HC1) and age-and gender-matched control group for DM2 (HC2). The subjects performed a basic walking task, dual-motor task, dual-mental task, and combined motor and mental task. Results: DM1 and DM2 patients differed significantly in temporal and stride characteristics compared to HC. Main differences in DM1 were slower gait and shorter stride length, while both DM1 and DM2 patients had a higher degree of variation of the swing time during dual-task gait, a parameter that reflects posture and balance. Impact of the cognitive dual task on gait pattern changes was also observed. Visuospatial ability correlated with gait changes in DM1, while executive functions had stronger influence in DM2 (p lt 0.01). Both patient groups had leg muscle weakness. Conclusion: Gait pattern was impaired in both patient groups concerning temporal and stride characteristics. Dual-task walking paradigm may discover mild initial gait changes and could provide early identification of fall risks and predict possible falls in DM patients.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Gait & Posture", title = "Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking", pages = "199-194", volume = "44", doi = "10.1016/j.gaitpost.2015.12.020" }
Radovanović, S. M., Perić, S., Savić-Pavićević, D., Dobricić, V., Pesović, J., Kostić, V. S.,& Rakočević-Stojanović, V.. (2016). Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking. in Gait & Posture Elsevier Ireland Ltd, Clare., 44, 194-199. https://doi.org/10.1016/j.gaitpost.2015.12.020
Radovanović SM, Perić S, Savić-Pavićević D, Dobricić V, Pesović J, Kostić VS, Rakočević-Stojanović V. Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking. in Gait & Posture. 2016;44:194-199. doi:10.1016/j.gaitpost.2015.12.020 .
Radovanović, Saša M., Perić, Stojan, Savić-Pavićević, D., Dobricić, V., Pesović, J., Kostić, Vladimir S., Rakočević-Stojanović, V., "Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking" in Gait & Posture, 44 (2016):194-199, https://doi.org/10.1016/j.gaitpost.2015.12.020 . .