Приказ основних података о документу
An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio
dc.creator | Knez, Marija | |
dc.creator | Stangoulis, James C. R. | |
dc.creator | Zec, Manja M. | |
dc.creator | Debeljak-Martačić, Jasmina | |
dc.creator | Pavlović, Zoran | |
dc.creator | Gurinović, Mirjana | |
dc.creator | Glibetić, Marija | |
dc.date.accessioned | 2021-04-20T12:47:46Z | |
dc.date.available | 2021-04-20T12:47:46Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2405-4577 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/706 | |
dc.description.abstract | Background: Zinc is an essential micronutrient for humans with important physiological functions. A sensitive and specific biomarker for assessing Zn status is still needed. Objective: The major aim of this study was to examine if the changes in the content of plasma phospholipid LA, DGLA and LA: DGLA ratio can be used to efficiently predict the dietary Zn intake and plasma Zn status of humans. Methods: The study was performed on healthy human volunteers, 25-55 years of age. The dietary Zn intake was assessed using 24 h recall questionnaires. Plasma phospholipid fatty acid analysis was done by gas chromatography, and plasma analysis of minerals by atomic absorption spectrometry. Biochemical, anthropometrical and hematological parameters were assessed. Results: No significant relationship was found between the dietary and plasma zinc status (r = 0.07; p = 0.6). There was a statistically significant correlation between DGLA and plasma Zn (r = 0.39, p = 0.00). No relationship was observed between the linoleic acid and plasma Zn, while there was a significant negative correlation between LA: DGLA ratio and plasma Zn status (r = 0.35, p = 0.01). Similarly, there were statistically significant difference in DGLA status (p = 0.004) and LA: DGLA ratio (p = 0.042) between the Zn formed groups. Conclusions: This study is an initial step in evaluating LA: DGLA ratio as a biomarker of Zn status in humans. The results are encouraging as they show that concentration of DGLA is decreased and LA: DGLA ratio increased in people with lower dietary Zn intake. However, additional studies are needed to fully examine the sensitivity of this biomarker. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS// | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/312090/EU// | |
dc.relation | Australian Postgraduate AwardAustralian Government | |
dc.rights | openAccess | |
dc.source | Clinical Nutrition ESPEN | |
dc.subject | Zinc | en |
dc.subject | Fatty acid composition | en |
dc.subject | LA: DGLA | en |
dc.subject | Healthy population | en |
dc.subject | Dietary Zn intake | en |
dc.subject | Plasma Zn status | en |
dc.subject | Zn biomarker | en |
dc.title | An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 92 | |
dc.citation.other | 15: 85-92 | |
dc.citation.spage | 85 | |
dc.citation.volume | 15 | |
dc.identifier.doi | 10.1016/j.clnesp.2016.06.013 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/535/703.pdf | |
dc.identifier.pmid | 28531790 | |
dc.identifier.scopus | 2-s2.0-84989223343 | |
dc.identifier.wos | 000446651700015 | |
dc.type.version | publishedVersion |