Приказ основних података о документу
Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow
dc.creator | Jovčić, Gordana | |
dc.creator | Bugarski, Diana | |
dc.creator | Petakov, Marijana | |
dc.creator | Stanković, J | |
dc.creator | Stojanović, N. | |
dc.creator | Milenković, P. | |
dc.date.accessioned | 2021-04-20T12:06:01Z | |
dc.date.available | 2021-04-20T12:06:01Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0897-7194 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/68 | |
dc.description.abstract | The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | restrictedAccess | |
dc.source | Growth Factors | |
dc.subject | IL-17 | en |
dc.subject | hematopoietic progenitors | en |
dc.subject | cytokine release | en |
dc.subject | murine bone marrow | en |
dc.title | Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 71 | |
dc.citation.issue | 1 | |
dc.citation.other | 19(1): 61-71 | |
dc.citation.rank | M22 | |
dc.citation.spage | 61 | |
dc.citation.volume | 19 | |
dc.identifier.doi | 10.3109/08977190109001076 | |
dc.identifier.pmid | 11678210 | |
dc.identifier.scopus | 2-s2.0-0034795602 | |
dc.identifier.wos | 000171616200005 | |
dc.type.version | publishedVersion |