Приказ основних података о документу
Urokinase type plasminogen activator mediates Interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration
dc.creator | Krstić, Jelena | |
dc.creator | Obradović, Hristina | |
dc.creator | Jauković, Aleksandra | |
dc.creator | Okić Đorđević, Ivana | |
dc.creator | Trivanović, Drenka | |
dc.creator | Kukolj, Tamara | |
dc.creator | Mojsilović, Slavko | |
dc.creator | Ilić, Vesna | |
dc.creator | Santibanez, Juan F. | |
dc.creator | Bugarski, Diana | |
dc.date.accessioned | 2021-04-20T12:45:16Z | |
dc.date.available | 2021-04-20T12:45:16Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0167-4889 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/666 | |
dc.description.abstract | Mesenchymal stem cells (MSCs) have the potential to migrate toward damaged tissues increasing tissue regeneration. Interleukin-17 (IL-17) is a proinflammatory cytokine with pleiotropic effects associated with many inflammatory diseases. Although IL-17 can modulate MSC functions, its capacity to regulate MSC migration is not well elucidated so far. Here, we studied the role of IL-17 on peripheral blood (PB) derived MSC migration and transmigration across endothelial cells. IL-17 increased PB-MSC migration in a wound healing assay as well as cell mobilization from collagen gel. Concomitantly IL-17 induced the expression of urokinase type plasminogen activator (uPA) without affecting matrix metalloproteinase expression. The incremented uPA expression mediated the capacity of IL-17 to enhance PB-MSC migration in a ERK1,2 MAPK dependent way. Also, IL-17 induced PB-MSC migration alongside with changes in cell polarization and uPA localization in cell protrusions. Moreover, IL-17 increased PB-MSC adhesion to endothelial cells and transendothelial migration, as well as increased the capacity of PB-MSC adhesion to fibronectin, in an uPA-dependent fashion. Therefore, our data suggested that IL-17 may act as chemotropic factor for PB-MSCs by incrementing cell motility and uPA expression during inflammation development. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS// | |
dc.rights | openAccess | |
dc.source | Biochimica et Biophysica Acta-Molecular Cell Research | |
dc.subject | Interleukin-17 | en |
dc.subject | Peripheral blood mesenchymal stem cells | en |
dc.subject | Urokinase type plasminogen activator | en |
dc.subject | Migration | en |
dc.subject | Transendothelial migration | en |
dc.title | Urokinase type plasminogen activator mediates Interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 444 | |
dc.citation.issue | 2 | |
dc.citation.other | 1853(2): 431-444 | |
dc.citation.rank | M21 | |
dc.citation.spage | 431 | |
dc.citation.volume | 1853 | |
dc.identifier.doi | 10.1016/j.bbamcr.2014.11.025 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/508/663.pdf | |
dc.identifier.pmid | 25433194 | |
dc.identifier.scopus | 2-s2.0-84916910734 | |
dc.identifier.wos | 000348554600017 | |
dc.type.version | publishedVersion |