Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning
Само за регистроване кориснике
2015
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: To evaluate the differential effects on motor learning of two types of theta burst stimulation (TBS), the excitatory intermittent TBS (iTBS) and inhibitory continuous TBS (cTBS), if TBS is applied in an early stage of learning process. Methods: Thirty right handed healthy people were randomly allocated into one of the three groups according to the intervention applied, iTBS, cTBS or placebo. The interventions and measurements targeted the non-dominant side. The reaction time task (RTT) and Purdue pegboard task (PPT) were used. Measurements and motor tasks were carried out at baseline (T0), immediately after the intervention (T1), and 30 min later (T2). Results: Compared to placebo, following cTBS M1 excitability went down and PPT learning was slowed. Following iTBS M1 excitability increased temporarily and PPT learning pattern changed, but learning was not improved. The MEP and PPT changes induced during the T0-T1 time interval correlated significantly. Conclusions: The earl...y consolidation of the learned material was much more influenced by the TBS induced promotion/suppression of the M1 functional plasticity reserves than by the absolute level of the M1 activation. Significance: The results may help to better define the use of TBS in promotion of motor learning in neurorehabilitation and cognitive enhancement.
Кључне речи:
Motor learning / Primary motor cortex / Transcranial magnetic stimulation / Neuromodulation / PlasticityИзвор:
Clinical Neurophysiology, 2015, 126, 5, 1016-1023Издавач:
- Elsevier Ireland Ltd, Clare
Финансирање / пројекти:
- Неинвазивна модулација кортикалне ексцитабилности и пластицитета - Развој метода неинвазивне неуромодулације централног нервног система у испитивања физиолошких механизама, дијагностици и терапији (RS-MESTD-Basic Research (BR or ON)-175012)
DOI: 10.1016/j.clinph.2014.09.003
ISSN: 1388-2457
PubMed: 25281475
WoS: 000352233500023
Scopus: 2-s2.0-84926145196
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Jelić, Milan AU - Milanović, Slađan AU - Filipović, Saša PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/624 AB - Objective: To evaluate the differential effects on motor learning of two types of theta burst stimulation (TBS), the excitatory intermittent TBS (iTBS) and inhibitory continuous TBS (cTBS), if TBS is applied in an early stage of learning process. Methods: Thirty right handed healthy people were randomly allocated into one of the three groups according to the intervention applied, iTBS, cTBS or placebo. The interventions and measurements targeted the non-dominant side. The reaction time task (RTT) and Purdue pegboard task (PPT) were used. Measurements and motor tasks were carried out at baseline (T0), immediately after the intervention (T1), and 30 min later (T2). Results: Compared to placebo, following cTBS M1 excitability went down and PPT learning was slowed. Following iTBS M1 excitability increased temporarily and PPT learning pattern changed, but learning was not improved. The MEP and PPT changes induced during the T0-T1 time interval correlated significantly. Conclusions: The early consolidation of the learned material was much more influenced by the TBS induced promotion/suppression of the M1 functional plasticity reserves than by the absolute level of the M1 activation. Significance: The results may help to better define the use of TBS in promotion of motor learning in neurorehabilitation and cognitive enhancement. PB - Elsevier Ireland Ltd, Clare T2 - Clinical Neurophysiology T1 - Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning EP - 1023 IS - 5 SP - 1016 VL - 126 DO - 10.1016/j.clinph.2014.09.003 ER -
@article{ author = "Jelić, Milan and Milanović, Slađan and Filipović, Saša", year = "2015", abstract = "Objective: To evaluate the differential effects on motor learning of two types of theta burst stimulation (TBS), the excitatory intermittent TBS (iTBS) and inhibitory continuous TBS (cTBS), if TBS is applied in an early stage of learning process. Methods: Thirty right handed healthy people were randomly allocated into one of the three groups according to the intervention applied, iTBS, cTBS or placebo. The interventions and measurements targeted the non-dominant side. The reaction time task (RTT) and Purdue pegboard task (PPT) were used. Measurements and motor tasks were carried out at baseline (T0), immediately after the intervention (T1), and 30 min later (T2). Results: Compared to placebo, following cTBS M1 excitability went down and PPT learning was slowed. Following iTBS M1 excitability increased temporarily and PPT learning pattern changed, but learning was not improved. The MEP and PPT changes induced during the T0-T1 time interval correlated significantly. Conclusions: The early consolidation of the learned material was much more influenced by the TBS induced promotion/suppression of the M1 functional plasticity reserves than by the absolute level of the M1 activation. Significance: The results may help to better define the use of TBS in promotion of motor learning in neurorehabilitation and cognitive enhancement.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Clinical Neurophysiology", title = "Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning", pages = "1023-1016", number = "5", volume = "126", doi = "10.1016/j.clinph.2014.09.003" }
Jelić, M., Milanović, S.,& Filipović, S.. (2015). Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning. in Clinical Neurophysiology Elsevier Ireland Ltd, Clare., 126(5), 1016-1023. https://doi.org/10.1016/j.clinph.2014.09.003
Jelić M, Milanović S, Filipović S. Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning. in Clinical Neurophysiology. 2015;126(5):1016-1023. doi:10.1016/j.clinph.2014.09.003 .
Jelić, Milan, Milanović, Slađan, Filipović, Saša, "Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning" in Clinical Neurophysiology, 126, no. 5 (2015):1016-1023, https://doi.org/10.1016/j.clinph.2014.09.003 . .