Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
2014
Аутори
Vignjević, SanjaBudeč, Mirela
Marković, Dragana
Đikić, Dragoslava
Mitrović, Olivera
Mojsilović, Slavko
Vranješ-Đurić, Sanja
Koko, Vesna
Beleslin-Čokić, Bojana
Čokić, Vladan
Jovčić, Gordana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot... analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation.
Кључне речи:
stress / erythropoiesis / BMP4 / spleenИзвор:
Journal of Cellular & Molecular Medicine, 2014, 18, 1, 91-103Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Испитивање патогенезе хематолошких малигнитета (RS-MESTD-Basic Research (BR or ON)-175053)
DOI: 10.1111/jcmm.12167
ISSN: 1582-1838
PubMed: 24283209
WoS: 000328951400009
Scopus: 2-s2.0-84891371102
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Vignjević, Sanja AU - Budeč, Mirela AU - Marković, Dragana AU - Đikić, Dragoslava AU - Mitrović, Olivera AU - Mojsilović, Slavko AU - Vranješ-Đurić, Sanja AU - Koko, Vesna AU - Beleslin-Čokić, Bojana AU - Čokić, Vladan AU - Jovčić, Gordana PY - 2014 UR - http://rimi.imi.bg.ac.rs/handle/123456789/575 AB - Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation. PB - Wiley, Hoboken T2 - Journal of Cellular & Molecular Medicine T1 - Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis EP - 103 IS - 1 SP - 91 VL - 18 DO - 10.1111/jcmm.12167 ER -
@article{ author = "Vignjević, Sanja and Budeč, Mirela and Marković, Dragana and Đikić, Dragoslava and Mitrović, Olivera and Mojsilović, Slavko and Vranješ-Đurić, Sanja and Koko, Vesna and Beleslin-Čokić, Bojana and Čokić, Vladan and Jovčić, Gordana", year = "2014", abstract = "Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation.", publisher = "Wiley, Hoboken", journal = "Journal of Cellular & Molecular Medicine", title = "Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis", pages = "103-91", number = "1", volume = "18", doi = "10.1111/jcmm.12167" }
Vignjević, S., Budeč, M., Marković, D., Đikić, D., Mitrović, O., Mojsilović, S., Vranješ-Đurić, S., Koko, V., Beleslin-Čokić, B., Čokić, V.,& Jovčić, G.. (2014). Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis. in Journal of Cellular & Molecular Medicine Wiley, Hoboken., 18(1), 91-103. https://doi.org/10.1111/jcmm.12167
Vignjević S, Budeč M, Marković D, Đikić D, Mitrović O, Mojsilović S, Vranješ-Đurić S, Koko V, Beleslin-Čokić B, Čokić V, Jovčić G. Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis. in Journal of Cellular & Molecular Medicine. 2014;18(1):91-103. doi:10.1111/jcmm.12167 .
Vignjević, Sanja, Budeč, Mirela, Marković, Dragana, Đikić, Dragoslava, Mitrović, Olivera, Mojsilović, Slavko, Vranješ-Đurić, Sanja, Koko, Vesna, Beleslin-Čokić, Bojana, Čokić, Vladan, Jovčić, Gordana, "Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis" in Journal of Cellular & Molecular Medicine, 18, no. 1 (2014):91-103, https://doi.org/10.1111/jcmm.12167 . .