BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer
2013
Аутори
Mitrović, OliveraMićić, Mileva
Čokić, Vladan
Koko, Vesna
Đikić, Dragoslava
Budeč, Mirela
Vignjević, Sanja
Breković, Tijana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients.
Кључне речи:
BRCA1 / TOP2A / FISH / immunohistochemistry / molecular subtypes of breast cancerИзвор:
Archives of Biological Sciences, 2013, 65, 2, 511-518Издавач:
- Srpsko biološko društvo, Beograd, i dr.
Финансирање / пројекти:
- Испитивање патогенезе хематолошких малигнитета (RS-MESTD-Basic Research (BR or ON)-175053)
DOI: 10.2298/ABS1302511M
ISSN: 0354-4664
WoS: 000318826000013
Scopus: 2-s2.0-84876957995
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Mitrović, Olivera AU - Mićić, Mileva AU - Čokić, Vladan AU - Koko, Vesna AU - Đikić, Dragoslava AU - Budeč, Mirela AU - Vignjević, Sanja AU - Breković, Tijana PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/465 AB - We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer EP - 518 IS - 2 SP - 511 VL - 65 DO - 10.2298/ABS1302511M ER -
@article{ author = "Mitrović, Olivera and Mićić, Mileva and Čokić, Vladan and Koko, Vesna and Đikić, Dragoslava and Budeč, Mirela and Vignjević, Sanja and Breković, Tijana", year = "2013", abstract = "We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer", pages = "518-511", number = "2", volume = "65", doi = "10.2298/ABS1302511M" }
Mitrović, O., Mićić, M., Čokić, V., Koko, V., Đikić, D., Budeč, M., Vignjević, S.,& Breković, T.. (2013). BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 65(2), 511-518. https://doi.org/10.2298/ABS1302511M
Mitrović O, Mićić M, Čokić V, Koko V, Đikić D, Budeč M, Vignjević S, Breković T. BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer. in Archives of Biological Sciences. 2013;65(2):511-518. doi:10.2298/ABS1302511M .
Mitrović, Olivera, Mićić, Mileva, Čokić, Vladan, Koko, Vesna, Đikić, Dragoslava, Budeč, Mirela, Vignjević, Sanja, Breković, Tijana, "BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer" in Archives of Biological Sciences, 65, no. 2 (2013):511-518, https://doi.org/10.2298/ABS1302511M . .