Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density
Само за регистроване кориснике
2012
Аутори
Mitrović, OliveraMićić, Mileva
Radenković, Goran
Vignjević, Sanja
Đikić, Dragoslava
Budeč, Mirela
Breković, Tijana
Čokić, Vladan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
While ghrelin cells were the most numerous during the se Since reports on endocrine cells and their kinetics in the corpus of the human stomach are limited, the aim of this study was to examine the appearance, localization, density, and the relationship among the endocrine cell types in the corpus of the human stomach during prenatal and early postnatal development. We examined chromogranin A, somatostatin, ghrelin, glucagon, and serotonin expression by immunohistochemistry in 2 embryos, 38 fetuses, and 3 infants in the corpus of human stomach. Chromogranin A secreting endocrine cells were identified in the corpus at week 10 of gestation. Somatostatin cells were present from the 10th week, ghrelin and serotonin cells from the 11th week, and glucagon cells from the 12th week of gestation. Endocrine cells were present individually or clustered within the glandular base and body during the first trimester, and were present separately within the basal and central parts of glands during the... second and third trimesters. Somatostatin cells were the most common type of cells (similar to 46 %) during the first trimestercond trimester (similar to 34 %), and in infants (similar to 28 %). The percentage of glucagon cells was significant only during the first trimester of pregnancy (5.5 %), and the percentage of serotonin cells was only significant just before birth (4.8 %). These results show, for the first time, that the largest number of endocrine cells are present in the corpus during the first trimester of prenatal development. Also, these results suggest that secretory products of endocrine cells play a role in the regulation of homeostasis, growth, and differentiation, and in human stomach function.
Кључне речи:
Stomach of human fetus / Development / Endocrine cells / ImmunohistochemistryИзвор:
Journal of Gastroenterology, 2012, 47, 11, 1212-1220Издавач:
- Springer Japan Kk, Tokyo
Финансирање / пројекти:
- Испитивање патогенезе хематолошких малигнитета (RS-MESTD-Basic Research (BR or ON)-175053)
DOI: 10.1007/s00535-012-0597-9
ISSN: 0944-1174
PubMed: 22544314
WoS: 000311399800005
Scopus: 2-s2.0-84872274867
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Mitrović, Olivera AU - Mićić, Mileva AU - Radenković, Goran AU - Vignjević, Sanja AU - Đikić, Dragoslava AU - Budeč, Mirela AU - Breković, Tijana AU - Čokić, Vladan PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/395 AB - While ghrelin cells were the most numerous during the se Since reports on endocrine cells and their kinetics in the corpus of the human stomach are limited, the aim of this study was to examine the appearance, localization, density, and the relationship among the endocrine cell types in the corpus of the human stomach during prenatal and early postnatal development. We examined chromogranin A, somatostatin, ghrelin, glucagon, and serotonin expression by immunohistochemistry in 2 embryos, 38 fetuses, and 3 infants in the corpus of human stomach. Chromogranin A secreting endocrine cells were identified in the corpus at week 10 of gestation. Somatostatin cells were present from the 10th week, ghrelin and serotonin cells from the 11th week, and glucagon cells from the 12th week of gestation. Endocrine cells were present individually or clustered within the glandular base and body during the first trimester, and were present separately within the basal and central parts of glands during the second and third trimesters. Somatostatin cells were the most common type of cells (similar to 46 %) during the first trimestercond trimester (similar to 34 %), and in infants (similar to 28 %). The percentage of glucagon cells was significant only during the first trimester of pregnancy (5.5 %), and the percentage of serotonin cells was only significant just before birth (4.8 %). These results show, for the first time, that the largest number of endocrine cells are present in the corpus during the first trimester of prenatal development. Also, these results suggest that secretory products of endocrine cells play a role in the regulation of homeostasis, growth, and differentiation, and in human stomach function. PB - Springer Japan Kk, Tokyo T2 - Journal of Gastroenterology T1 - Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density EP - 1220 IS - 11 SP - 1212 VL - 47 DO - 10.1007/s00535-012-0597-9 ER -
@article{ author = "Mitrović, Olivera and Mićić, Mileva and Radenković, Goran and Vignjević, Sanja and Đikić, Dragoslava and Budeč, Mirela and Breković, Tijana and Čokić, Vladan", year = "2012", abstract = "While ghrelin cells were the most numerous during the se Since reports on endocrine cells and their kinetics in the corpus of the human stomach are limited, the aim of this study was to examine the appearance, localization, density, and the relationship among the endocrine cell types in the corpus of the human stomach during prenatal and early postnatal development. We examined chromogranin A, somatostatin, ghrelin, glucagon, and serotonin expression by immunohistochemistry in 2 embryos, 38 fetuses, and 3 infants in the corpus of human stomach. Chromogranin A secreting endocrine cells were identified in the corpus at week 10 of gestation. Somatostatin cells were present from the 10th week, ghrelin and serotonin cells from the 11th week, and glucagon cells from the 12th week of gestation. Endocrine cells were present individually or clustered within the glandular base and body during the first trimester, and were present separately within the basal and central parts of glands during the second and third trimesters. Somatostatin cells were the most common type of cells (similar to 46 %) during the first trimestercond trimester (similar to 34 %), and in infants (similar to 28 %). The percentage of glucagon cells was significant only during the first trimester of pregnancy (5.5 %), and the percentage of serotonin cells was only significant just before birth (4.8 %). These results show, for the first time, that the largest number of endocrine cells are present in the corpus during the first trimester of prenatal development. Also, these results suggest that secretory products of endocrine cells play a role in the regulation of homeostasis, growth, and differentiation, and in human stomach function.", publisher = "Springer Japan Kk, Tokyo", journal = "Journal of Gastroenterology", title = "Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density", pages = "1220-1212", number = "11", volume = "47", doi = "10.1007/s00535-012-0597-9" }
Mitrović, O., Mićić, M., Radenković, G., Vignjević, S., Đikić, D., Budeč, M., Breković, T.,& Čokić, V.. (2012). Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density. in Journal of Gastroenterology Springer Japan Kk, Tokyo., 47(11), 1212-1220. https://doi.org/10.1007/s00535-012-0597-9
Mitrović O, Mićić M, Radenković G, Vignjević S, Đikić D, Budeč M, Breković T, Čokić V. Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density. in Journal of Gastroenterology. 2012;47(11):1212-1220. doi:10.1007/s00535-012-0597-9 .
Mitrović, Olivera, Mićić, Mileva, Radenković, Goran, Vignjević, Sanja, Đikić, Dragoslava, Budeč, Mirela, Breković, Tijana, Čokić, Vladan, "Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density" in Journal of Gastroenterology, 47, no. 11 (2012):1212-1220, https://doi.org/10.1007/s00535-012-0597-9 . .