Mesenchymal stem cell properties of dental pulp cells from deciduous teeth
2011
Аутори
Nikolić, N.Krstić, Aleksandra
Trivanović, Drenka
Mojsilović, S.
Kocić, Jelena
Santibanez, Juan F.
Jovčić, Gordana
Bugarski, Diana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In the present study we have isolated and identified mesenchymal stem cells (MSCs) from the exfoliated deciduous teeth dental pulp (DP-MSCs), as plastic-adherent, spindle-shaped cells with a high proliferative potential. Immunophenotype analyses revealed that DP-MSCs were positive for mesenchymal cell markers (CD90, CD44, CD105, STRO-1, vimentin and α-SMA), and negative for hematopoietic stem cell markers (CD11b, CD33, CD34, CD45, CD235a). DPMSCs were also capable of differentiating into adipogenic, chondrogenic, myogenic and osteogenic lineages, fulfilling the functional criterion for their characterization. These results demonstrate that DP-MSCs offer a valuable, readily accessible source to obtain and store adult stem cells for future use.
Кључне речи:
Dental pulp / deciduous teeth / mesenchymal stem cells / CFU-F / growth / differentiationИзвор:
Archives of Biological Sciences, 2011, 63, 4, 933-942Издавач:
- Srpsko biološko društvo, Beograd, i dr.
Финансирање / пројекти:
- Регенеративни и модулаторни потенцијал адултних матичних ћелија (RS-MESTD-Basic Research (BR or ON)-175062)
DOI: 10.2298/ABS1104933N
ISSN: 0354-4664
WoS: 000299244500003
Scopus: 2-s2.0-84857950393
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Nikolić, N. AU - Krstić, Aleksandra AU - Trivanović, Drenka AU - Mojsilović, S. AU - Kocić, Jelena AU - Santibanez, Juan F. AU - Jovčić, Gordana AU - Bugarski, Diana PY - 2011 UR - http://rimi.imi.bg.ac.rs/handle/123456789/350 AB - In the present study we have isolated and identified mesenchymal stem cells (MSCs) from the exfoliated deciduous teeth dental pulp (DP-MSCs), as plastic-adherent, spindle-shaped cells with a high proliferative potential. Immunophenotype analyses revealed that DP-MSCs were positive for mesenchymal cell markers (CD90, CD44, CD105, STRO-1, vimentin and α-SMA), and negative for hematopoietic stem cell markers (CD11b, CD33, CD34, CD45, CD235a). DPMSCs were also capable of differentiating into adipogenic, chondrogenic, myogenic and osteogenic lineages, fulfilling the functional criterion for their characterization. These results demonstrate that DP-MSCs offer a valuable, readily accessible source to obtain and store adult stem cells for future use. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Mesenchymal stem cell properties of dental pulp cells from deciduous teeth EP - 942 IS - 4 SP - 933 VL - 63 DO - 10.2298/ABS1104933N ER -
@article{ author = "Nikolić, N. and Krstić, Aleksandra and Trivanović, Drenka and Mojsilović, S. and Kocić, Jelena and Santibanez, Juan F. and Jovčić, Gordana and Bugarski, Diana", year = "2011", abstract = "In the present study we have isolated and identified mesenchymal stem cells (MSCs) from the exfoliated deciduous teeth dental pulp (DP-MSCs), as plastic-adherent, spindle-shaped cells with a high proliferative potential. Immunophenotype analyses revealed that DP-MSCs were positive for mesenchymal cell markers (CD90, CD44, CD105, STRO-1, vimentin and α-SMA), and negative for hematopoietic stem cell markers (CD11b, CD33, CD34, CD45, CD235a). DPMSCs were also capable of differentiating into adipogenic, chondrogenic, myogenic and osteogenic lineages, fulfilling the functional criterion for their characterization. These results demonstrate that DP-MSCs offer a valuable, readily accessible source to obtain and store adult stem cells for future use.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Mesenchymal stem cell properties of dental pulp cells from deciduous teeth", pages = "942-933", number = "4", volume = "63", doi = "10.2298/ABS1104933N" }
Nikolić, N., Krstić, A., Trivanović, D., Mojsilović, S., Kocić, J., Santibanez, J. F., Jovčić, G.,& Bugarski, D.. (2011). Mesenchymal stem cell properties of dental pulp cells from deciduous teeth. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 63(4), 933-942. https://doi.org/10.2298/ABS1104933N
Nikolić N, Krstić A, Trivanović D, Mojsilović S, Kocić J, Santibanez JF, Jovčić G, Bugarski D. Mesenchymal stem cell properties of dental pulp cells from deciduous teeth. in Archives of Biological Sciences. 2011;63(4):933-942. doi:10.2298/ABS1104933N .
Nikolić, N., Krstić, Aleksandra, Trivanović, Drenka, Mojsilović, S., Kocić, Jelena, Santibanez, Juan F., Jovčić, Gordana, Bugarski, Diana, "Mesenchymal stem cell properties of dental pulp cells from deciduous teeth" in Archives of Biological Sciences, 63, no. 4 (2011):933-942, https://doi.org/10.2298/ABS1104933N . .