Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes
Само за регистроване кориснике
2011
Аутори
Milanović, SlađanFilipović, Saša
Blesić, Suzana
Ilić, Tihomir V.
Dhanasekaran, S.
Ljubisavljević, Miloš
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to examine whether the changes of the motor cortex excitability induced by muscle fatigue could be affected by prior or subsequent intervention protocol supposed to induce opposing excitability changes. For this purpose we used paired associative stimulation (PAS) method, where peripheral nerve stimuli were associated with transcranial magnetic stimulation (TMS) of the motor cortex at a fixed interstimulus interval of 25 ms. The PAS protocol used is known to produce a long lasting, long-term potentiation (LTP) like change of cortical plasticity manifested by significant increase in motor evoked potentials (MEPs) amplitude. In this study, we confirmed significant MEP size reduction following fatigue, which had been already reported in the literature. When PAS was applied either immediately before or after muscle fatigue protocol, the excitability changes were largely occluded and MEP sizes remained close to baseline levels. However, in spite of the effects on c...ortical excitability, conditioning with PAS did not cause any change in target fatigue measure, the endurance point, which remained the same as when fatiguing protocol was applied alone. The present results demonstrate that fatigue-related changes in cortical excitability can be modulated by either prior or subsequent excitability promoting activity. They also suggest that muscle fatigue associated changes in motor cortical excitability probably represent non-specific activity-related plasticity, rather than a direct expression of the so-called central fatigue.
Кључне речи:
TMS / Brain plasticity / Motor cortex / Muscle fatigue / Paired associative stimulationИзвор:
Behavioural Brain Research, 2011, 223, 1, 30-35Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Неинвазивна модулација кортикалне ексцитабилности и пластицитета - Развој метода неинвазивне неуромодулације централног нервног система у испитивања физиолошких механизама, дијагностици и терапији (RS-175012)
- FMHS [NP-07-21]
DOI: 10.1016/j.bbr.2011.04.013
ISSN: 0166-4328
PubMed: 21515308
WoS: 000292587700005
Scopus: 2-s2.0-79955811347
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Milanović, Slađan AU - Filipović, Saša AU - Blesić, Suzana AU - Ilić, Tihomir V. AU - Dhanasekaran, S. AU - Ljubisavljević, Miloš PY - 2011 UR - http://rimi.imi.bg.ac.rs/handle/123456789/345 AB - The aim of this study was to examine whether the changes of the motor cortex excitability induced by muscle fatigue could be affected by prior or subsequent intervention protocol supposed to induce opposing excitability changes. For this purpose we used paired associative stimulation (PAS) method, where peripheral nerve stimuli were associated with transcranial magnetic stimulation (TMS) of the motor cortex at a fixed interstimulus interval of 25 ms. The PAS protocol used is known to produce a long lasting, long-term potentiation (LTP) like change of cortical plasticity manifested by significant increase in motor evoked potentials (MEPs) amplitude. In this study, we confirmed significant MEP size reduction following fatigue, which had been already reported in the literature. When PAS was applied either immediately before or after muscle fatigue protocol, the excitability changes were largely occluded and MEP sizes remained close to baseline levels. However, in spite of the effects on cortical excitability, conditioning with PAS did not cause any change in target fatigue measure, the endurance point, which remained the same as when fatiguing protocol was applied alone. The present results demonstrate that fatigue-related changes in cortical excitability can be modulated by either prior or subsequent excitability promoting activity. They also suggest that muscle fatigue associated changes in motor cortical excitability probably represent non-specific activity-related plasticity, rather than a direct expression of the so-called central fatigue. PB - Elsevier Science Bv, Amsterdam T2 - Behavioural Brain Research T1 - Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes EP - 35 IS - 1 SP - 30 VL - 223 DO - 10.1016/j.bbr.2011.04.013 ER -
@article{ author = "Milanović, Slađan and Filipović, Saša and Blesić, Suzana and Ilić, Tihomir V. and Dhanasekaran, S. and Ljubisavljević, Miloš", year = "2011", abstract = "The aim of this study was to examine whether the changes of the motor cortex excitability induced by muscle fatigue could be affected by prior or subsequent intervention protocol supposed to induce opposing excitability changes. For this purpose we used paired associative stimulation (PAS) method, where peripheral nerve stimuli were associated with transcranial magnetic stimulation (TMS) of the motor cortex at a fixed interstimulus interval of 25 ms. The PAS protocol used is known to produce a long lasting, long-term potentiation (LTP) like change of cortical plasticity manifested by significant increase in motor evoked potentials (MEPs) amplitude. In this study, we confirmed significant MEP size reduction following fatigue, which had been already reported in the literature. When PAS was applied either immediately before or after muscle fatigue protocol, the excitability changes were largely occluded and MEP sizes remained close to baseline levels. However, in spite of the effects on cortical excitability, conditioning with PAS did not cause any change in target fatigue measure, the endurance point, which remained the same as when fatiguing protocol was applied alone. The present results demonstrate that fatigue-related changes in cortical excitability can be modulated by either prior or subsequent excitability promoting activity. They also suggest that muscle fatigue associated changes in motor cortical excitability probably represent non-specific activity-related plasticity, rather than a direct expression of the so-called central fatigue.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Behavioural Brain Research", title = "Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes", pages = "35-30", number = "1", volume = "223", doi = "10.1016/j.bbr.2011.04.013" }
Milanović, S., Filipović, S., Blesić, S., Ilić, T. V., Dhanasekaran, S.,& Ljubisavljević, M.. (2011). Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes. in Behavioural Brain Research Elsevier Science Bv, Amsterdam., 223(1), 30-35. https://doi.org/10.1016/j.bbr.2011.04.013
Milanović S, Filipović S, Blesić S, Ilić TV, Dhanasekaran S, Ljubisavljević M. Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes. in Behavioural Brain Research. 2011;223(1):30-35. doi:10.1016/j.bbr.2011.04.013 .
Milanović, Slađan, Filipović, Saša, Blesić, Suzana, Ilić, Tihomir V., Dhanasekaran, S., Ljubisavljević, Miloš, "Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes" in Behavioural Brain Research, 223, no. 1 (2011):30-35, https://doi.org/10.1016/j.bbr.2011.04.013 . .