Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease
Само за регистроване кориснике
2010
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1 Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecuti...ve daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days.
Кључне речи:
Repetitive transcranial magnetic stimulation / rTMS / Parkinson's disease / Placebo / Motor symptomsИзвор:
Journal of the Neurological Sciences, 2010, 291, 1-2, 1-4Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Parkinson's Disease Society of the United Kingdom [4034]
- Кортикална ексцитабилност и пластицитет код здравих испитаника и пацијената оболелих од поремећаја моторике – неурофизиолошка испитивања механизама настанка, могућности модулације, функционалног и терапијског значаја (RS-MESTD-MPN2006-2010-145083)
DOI: 10.1016/j.jns.2010.01.017
ISSN: 0022-510X
PubMed: 20153482
WoS: 000276624200001
Scopus: 2-s2.0-77549087806
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Filipović, Saša AU - Rothwell, John C. AU - Bhatia, Kailash PY - 2010 UR - http://rimi.imi.bg.ac.rs/handle/123456789/290 AB - Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1 Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecutive daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days. PB - Elsevier Science Bv, Amsterdam T2 - Journal of the Neurological Sciences T1 - Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease EP - 4 IS - 1-2 SP - 1 VL - 291 DO - 10.1016/j.jns.2010.01.017 ER -
@article{ author = "Filipović, Saša and Rothwell, John C. and Bhatia, Kailash", year = "2010", abstract = "Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1 Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecutive daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of the Neurological Sciences", title = "Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease", pages = "4-1", number = "1-2", volume = "291", doi = "10.1016/j.jns.2010.01.017" }
Filipović, S., Rothwell, J. C.,& Bhatia, K.. (2010). Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease. in Journal of the Neurological Sciences Elsevier Science Bv, Amsterdam., 291(1-2), 1-4. https://doi.org/10.1016/j.jns.2010.01.017
Filipović S, Rothwell JC, Bhatia K. Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease. in Journal of the Neurological Sciences. 2010;291(1-2):1-4. doi:10.1016/j.jns.2010.01.017 .
Filipović, Saša, Rothwell, John C., Bhatia, Kailash, "Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease" in Journal of the Neurological Sciences, 291, no. 1-2 (2010):1-4, https://doi.org/10.1016/j.jns.2010.01.017 . .