Приказ основних података о документу
The prognosis of patients with dissociated virological and immunological responses to HAART
dc.creator | Jevtović, Đorđe | |
dc.creator | Salemović, Dubravka | |
dc.creator | Ranin, Jovan | |
dc.creator | Pešić-Pavlović, I. | |
dc.creator | Korac, M. | |
dc.creator | Đurković-Đaković, Olgica | |
dc.date.accessioned | 2021-04-20T12:20:30Z | |
dc.date.available | 2021-04-20T12:20:30Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/284 | |
dc.description.abstract | Background. - While HAART allows for the reconstitution of immune functions in most treated HIV patients, failure to achieve a significant increase in circulating CD4+ T cells despite undetectable viremia occurs. Methods. - A retrospective study was conducted to evaluate the treatment outcome in a subgroup of 232 patients who after 3.1 years of treatment had not achieved desirable immune reconstitution despite a good virological response to HAART. Results. - After a further 3.6 +/- 2.4 years of HAART, 82 (35.3%) patients achieved immune reconstitution (565.2 +/- 174.6 CD4 cells/mu l), while 149(64.2%) patients did not (268.8 +/- 91.1 cells/mu l); the difference in the achieved CD4 counts between these subgroups was significant (P lt 0.01). One patient experienced treatment failure. Eleven patients died to the end of follow-up, of which 10 with a continuously dissociated response. Factors associated with immune recovery included clinical AIDS at HAART initiation (OR: 0.4,95% Cl: 0.24-0.81, P lt 0.01), usage of PIs and of drugs from all three classes (OR: 1.7,95% CI: 1.0-3.0, P = 0.046 and OR: 4.5, 95% CI: 1.15-18.19, P = 0.03, respectively), and a rise in CD4 count to over 200 cells/mu l after the first 3.1 years of treatment (OR: 5.3 95% CI: 2.6-11.0, P lt 0.01). Achievement of a rise in CD4 count to over 200 cells/mu l after the first 3.1 years of treatment was an independent predictor of immune reconstitution in the following period. Conclusion. - If patients on HAART reach CD4 cell counts of above 200 cells/mu l in the first 3 years, immune recovery is possible after at least 6 years of treatment. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145002/RS// | |
dc.rights | restrictedAccess | |
dc.source | Biomedicine & Pharmacotherapy | |
dc.subject | HIV | en |
dc.subject | HAART | en |
dc.subject | Virological/immunological dissociation | en |
dc.title | The prognosis of patients with dissociated virological and immunological responses to HAART | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 696 | |
dc.citation.issue | 10 | |
dc.citation.other | 64(10): 692-696 | |
dc.citation.rank | M22 | |
dc.citation.spage | 692 | |
dc.citation.volume | 64 | |
dc.identifier.doi | 10.1016/j.biopha.2010.08.004 | |
dc.identifier.pmid | 20863649 | |
dc.identifier.scopus | 2-s2.0-78649842995 | |
dc.identifier.wos | 000286087600008 | |
dc.type.version | publishedVersion |