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The prognosis of CMV retinitis among patients with AIDS in Serbia
dc.creator | Dujić, A. | |
dc.creator | Jevtović, Đorđe | |
dc.creator | Salemović, Dubravka | |
dc.creator | Ranin, Jovan | |
dc.creator | Brmbolić, Branko | |
dc.creator | Đurković-Đaković, Olgica | |
dc.date.accessioned | 2021-04-20T12:15:32Z | |
dc.date.available | 2021-04-20T12:15:32Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/211 | |
dc.description.abstract | Background: Cytomegalovirus (CMV) end-organ diseases, including CMV retinitis, are major opportunistic events in terminal AIDS patients. Methods: A retrospective study of 30 AIDS patients with CMV retinitis treated between 1997 and 2007 in Serbia was conducted to examine the prognosis and factors associated with survival. Results: Eighteen (60%) patients survived the mean follow-up period of 46.4 +/- 36 months. Patients' sex, mode of HIV transmission or previous AIDS diagnosis did not affect survival. Bilateral CMV retinitis predicted dissemination of CMV disease and poor prognosis (OR 7.8, 95% Cl 1.3-47.0, P = 0.012), but was not associated with blindness (P = 0.33). Among patients treated with HAART and CMV therapy the probability of surviving 10 years was 70%, while in those on CMV therapy alone, the median survival was 10 months (log rank P = 0.00). However, HAART itself was not sufficient to prevent blindness and the major predictor of blindness was a baseline CD4 cell count of less than 50/mu L (OR 6.8, 95% Cl 1.1-41.8, P = 0.03). After CMV disease, most patients suffered other opportunistic events regardless of HAART introduction. Conclusion: Even in the HAART era patients with advanced immunodeficiency and CMV retinitis may not escape from the high risk mortality group, while survivors commonly lose sight. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145002/RS// | |
dc.rights | restrictedAccess | |
dc.source | Biomedicine & Pharmacotherapy | |
dc.subject | AIDS | en |
dc.subject | CMV retinitis | en |
dc.subject | survival | en |
dc.title | The prognosis of CMV retinitis among patients with AIDS in Serbia | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 447 | |
dc.citation.issue | 7 | |
dc.citation.other | 62(7): 443-447 | |
dc.citation.rank | M22 | |
dc.citation.spage | 443 | |
dc.citation.volume | 62 | |
dc.identifier.doi | 10.1016/j.biopha.2007.12.011 | |
dc.identifier.pmid | 18243635 | |
dc.identifier.scopus | 2-s2.0-48349118363 | |
dc.identifier.wos | 000259357500031 | |
dc.type.version | publishedVersion |