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Potential anti-melanoma activity of Imidazoline I1 receptor agonists
(European Association for Cancer Research, 2020)
Melanoma is the deadliest form of skin cancer. Despite the advancements in targeted
BRAF and MEK therapy and immunotherapies, metastatic melanoma patients still
have poor prognosis with a median survival of 9 months ...
The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)
The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA) or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects of stearic acid (SA) and ...
Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet
(Hindawi, 2021)
The benefits of walnut (Juglans regia) consumption for metabolic health are known, but the molecular background underlying their putative antioxidant and anti-inflammatory/immunomodulatory effects is underexplored. We ...
Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men
(Endocrine Soc, Chevy Chase, 2012)
Context: High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol in women. This may be due to gender differences in ...
P1002: Anti-fibrotic activity of BMP2 in bone marrow-derived mesenchymal stromal cells of myeloproliferative neoplasms
(Wolters Kluwer Health, Inc., 2022)
Background: Myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders that include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Bone marrow fibrosis (BMF) is a shared ...
Analyses of risk factors predicting the thrombotic complications in long-term follow up of 207 patients with essential thrombocythemia
(Ferrata Storti Foundation, Pavia, 2012)
Inflammation Promotes Oxidative and Nitrosative Stress in Chronic Myelogenous Leukemia
(MDPI, 2022)
Chronic inflammation is characterized by the production of reactive oxygen species (ROS), reactive nitrogen species, and inflammatory cytokines in myeloproliferative neoplasms (MPNs). In addition to these parameters, the ...
Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity
(Hindawi Limited, 2014)
The aim of this study was to analyze the effects of a 4-week-long consumption of glucomannan-enriched, aronia juice-based supplement on anthropometric parameters, membrane fatty acid profile, and status of antioxidant ...
PB1832: Inflammation induced coagulation in acute myeloid leukemia
(Wolters Kluwer Health, Inc., 2023)
Background: Patients with acute myeloid leukemia (AML) have an increased risk of thrombotic complications in the range of 4.2 - 5.2%.
Aims: Our hypothesis is that inflammation is responsible for deterioration of coagulation ...
Hematopoietic microenvironment / Mikrosredina hematopoeze
(Društvo hematologa Srbije, Beograd, 2003)
Steady-state hematopoiesis takes place in the bone marrow permissive microenvironment, composed of stromal cells, as well as extracellular matrix (ECM) components and regulatory molecules, produced by both stromal and ...