Gender Difference in SARS-CoV-2 Stimulation of Hyperinflammatory Response in Patients with COVID-19
Аутори
Mitrović-Ajtić, OliveraSubotički, Tijana
Miljatović, Sanja
Beleslin-Čokić, Bojana
Čokić, Vladan
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Although women and men have the same prevalence, men with
COVID-19 are more at risk for worse outcomes and death, independent of age.
Methods: To observe the hyperinflammatory response regarding sex, we will measure
the levels of inflammatory cytokines: interleukin-6 (IL-6), IL-1β, tumor necrosis
factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), IL-10, interferon-
gamma (IFN-γ), IL-8, transforming growth factor-beta 1 (TGF-β1), analyzed by
ELISA, in plasma of 130 COVID-19 patients at diagnosis and correlate them with clinical
parameters. Besides, we checked the quality of life of patients up to 3 months
after hospitalization.
Results: Pro-inflammatory IL-6 was significantly (p<0.01) increased in male COVID-19
patients compared to healthy male volunteers (4.7-fold) and female COVID-19 patients
(1.75-fold). IL-6 was positively correlated to INR, aPTT (p<0.001), and ferritin (p<0.05),
while INR with CRP (p<0.05). IL-8 was significantly increased in ...female COVID-19 patients
compared to healthy female volunteers (p<0.01, 2.5-fold) and male COVID-19 patients
(p<0.05). TNF-α was significantly (p<0.05) increased in male COVID-19 patients
compared to healthy male volunteers. MCP-1 and IFN-γ were significantly increased
in female COVID-19 patients compared to healthy female volunteers (p<0.01). Anti-inflammatory
TGF-β1 was decreased in COVID-19 patients regardless of gender. Most
patients were men (75%) with chronic disorders (59%, mostly hypertension). COVID-19
reduced their social (32%) and physical activities (34%) after 6 weeks of diagnosis, but
further on reduced in additional 3 months (social 55%) with depression (22%).
Conclusions: Inflammatory response is generally increased in COVID-19 patients
with specific cytokines in accordance with gender.
Извор:
The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022, 2022, 95-95Издавач:
- Belgrade: MEDAPP Association
Институција/група
Institut za medicinska istraživanjaTY - CONF AU - Mitrović-Ajtić, Olivera AU - Subotički, Tijana AU - Miljatović, Sanja AU - Beleslin-Čokić, Bojana AU - Čokić, Vladan PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1456 AB - Background: Although women and men have the same prevalence, men with COVID-19 are more at risk for worse outcomes and death, independent of age. Methods: To observe the hyperinflammatory response regarding sex, we will measure the levels of inflammatory cytokines: interleukin-6 (IL-6), IL-1β, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), IL-10, interferon- gamma (IFN-γ), IL-8, transforming growth factor-beta 1 (TGF-β1), analyzed by ELISA, in plasma of 130 COVID-19 patients at diagnosis and correlate them with clinical parameters. Besides, we checked the quality of life of patients up to 3 months after hospitalization. Results: Pro-inflammatory IL-6 was significantly (p<0.01) increased in male COVID-19 patients compared to healthy male volunteers (4.7-fold) and female COVID-19 patients (1.75-fold). IL-6 was positively correlated to INR, aPTT (p<0.001), and ferritin (p<0.05), while INR with CRP (p<0.05). IL-8 was significantly increased in female COVID-19 patients compared to healthy female volunteers (p<0.01, 2.5-fold) and male COVID-19 patients (p<0.05). TNF-α was significantly (p<0.05) increased in male COVID-19 patients compared to healthy male volunteers. MCP-1 and IFN-γ were significantly increased in female COVID-19 patients compared to healthy female volunteers (p<0.01). Anti-inflammatory TGF-β1 was decreased in COVID-19 patients regardless of gender. Most patients were men (75%) with chronic disorders (59%, mostly hypertension). COVID-19 reduced their social (32%) and physical activities (34%) after 6 weeks of diagnosis, but further on reduced in additional 3 months (social 55%) with depression (22%). Conclusions: Inflammatory response is generally increased in COVID-19 patients with specific cytokines in accordance with gender. PB - Belgrade: MEDAPP Association C3 - The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022 T1 - Gender Difference in SARS-CoV-2 Stimulation of Hyperinflammatory Response in Patients with COVID-19 EP - 95 SP - 95 UR - https://hdl.handle.net/21.15107/rcub_rimi_1456 ER -
@conference{ author = "Mitrović-Ajtić, Olivera and Subotički, Tijana and Miljatović, Sanja and Beleslin-Čokić, Bojana and Čokić, Vladan", year = "2022", abstract = "Background: Although women and men have the same prevalence, men with COVID-19 are more at risk for worse outcomes and death, independent of age. Methods: To observe the hyperinflammatory response regarding sex, we will measure the levels of inflammatory cytokines: interleukin-6 (IL-6), IL-1β, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), IL-10, interferon- gamma (IFN-γ), IL-8, transforming growth factor-beta 1 (TGF-β1), analyzed by ELISA, in plasma of 130 COVID-19 patients at diagnosis and correlate them with clinical parameters. Besides, we checked the quality of life of patients up to 3 months after hospitalization. Results: Pro-inflammatory IL-6 was significantly (p<0.01) increased in male COVID-19 patients compared to healthy male volunteers (4.7-fold) and female COVID-19 patients (1.75-fold). IL-6 was positively correlated to INR, aPTT (p<0.001), and ferritin (p<0.05), while INR with CRP (p<0.05). IL-8 was significantly increased in female COVID-19 patients compared to healthy female volunteers (p<0.01, 2.5-fold) and male COVID-19 patients (p<0.05). TNF-α was significantly (p<0.05) increased in male COVID-19 patients compared to healthy male volunteers. MCP-1 and IFN-γ were significantly increased in female COVID-19 patients compared to healthy female volunteers (p<0.01). Anti-inflammatory TGF-β1 was decreased in COVID-19 patients regardless of gender. Most patients were men (75%) with chronic disorders (59%, mostly hypertension). COVID-19 reduced their social (32%) and physical activities (34%) after 6 weeks of diagnosis, but further on reduced in additional 3 months (social 55%) with depression (22%). Conclusions: Inflammatory response is generally increased in COVID-19 patients with specific cytokines in accordance with gender.", publisher = "Belgrade: MEDAPP Association", journal = "The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022", title = "Gender Difference in SARS-CoV-2 Stimulation of Hyperinflammatory Response in Patients with COVID-19", pages = "95-95", url = "https://hdl.handle.net/21.15107/rcub_rimi_1456" }
Mitrović-Ajtić, O., Subotički, T., Miljatović, S., Beleslin-Čokić, B.,& Čokić, V.. (2022). Gender Difference in SARS-CoV-2 Stimulation of Hyperinflammatory Response in Patients with COVID-19. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022 Belgrade: MEDAPP Association., 95-95. https://hdl.handle.net/21.15107/rcub_rimi_1456
Mitrović-Ajtić O, Subotički T, Miljatović S, Beleslin-Čokić B, Čokić V. Gender Difference in SARS-CoV-2 Stimulation of Hyperinflammatory Response in Patients with COVID-19. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022. 2022;:95-95. https://hdl.handle.net/21.15107/rcub_rimi_1456 .
Mitrović-Ajtić, Olivera, Subotički, Tijana, Miljatović, Sanja, Beleslin-Čokić, Bojana, Čokić, Vladan, "Gender Difference in SARS-CoV-2 Stimulation of Hyperinflammatory Response in Patients with COVID-19" in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022 (2022):95-95, https://hdl.handle.net/21.15107/rcub_rimi_1456 .