Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients
Аутори
Rašić-Milutinović, ZoricaPeruničić, Gordana
Plješa, Steva
Gluvić, Zoran M.
Šobajić, Slađana
Đuričić, Ivana
Ristić, Danijela
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementati...on (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.
Кључне речи:
end-stage renal disease / insulin resistance / n-6 PUFAs / n-3 PUFAs / inflammatory marker TNF-alphaИзвор:
Reproductive Toxicology, 2007, 29, 3, 321-329Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Развој нових терапијских поступака у превенцији и лечењу болести јетре: Улога и механизам деловања полинезасићених масних киселина (RS-MESTD-MPN2006-2010-145071)
DOI: 10.1080/08860220601184092
ISSN: 0886-022X
PubMed: 17497447
WoS: 000246884800012
Scopus: 2-s2.0-34248588309
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Rašić-Milutinović, Zorica AU - Peruničić, Gordana AU - Plješa, Steva AU - Gluvić, Zoran M. AU - Šobajić, Slađana AU - Đuričić, Ivana AU - Ristić, Danijela PY - 2007 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1382 AB - Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented. PB - Taylor & Francis Ltd, Abingdon T2 - Reproductive Toxicology T1 - Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients EP - 329 IS - 3 SP - 321 VL - 29 DO - 10.1080/08860220601184092 ER -
@article{ author = "Rašić-Milutinović, Zorica and Peruničić, Gordana and Plješa, Steva and Gluvić, Zoran M. and Šobajić, Slađana and Đuričić, Ivana and Ristić, Danijela", year = "2007", abstract = "Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Reproductive Toxicology", title = "Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients", pages = "329-321", number = "3", volume = "29", doi = "10.1080/08860220601184092" }
Rašić-Milutinović, Z., Peruničić, G., Plješa, S., Gluvić, Z. M., Šobajić, S., Đuričić, I.,& Ristić, D.. (2007). Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. in Reproductive Toxicology Taylor & Francis Ltd, Abingdon., 29(3), 321-329. https://doi.org/10.1080/08860220601184092
Rašić-Milutinović Z, Peruničić G, Plješa S, Gluvić ZM, Šobajić S, Đuričić I, Ristić D. Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. in Reproductive Toxicology. 2007;29(3):321-329. doi:10.1080/08860220601184092 .
Rašić-Milutinović, Zorica, Peruničić, Gordana, Plješa, Steva, Gluvić, Zoran M., Šobajić, Slađana, Đuričić, Ivana, Ristić, Danijela, "Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients" in Reproductive Toxicology, 29, no. 3 (2007):321-329, https://doi.org/10.1080/08860220601184092 . .