dc.creator | Petrović, Anđelija | |
dc.creator | Čanković, Miloš | |
dc.creator | Avramov, Miloš | |
dc.creator | Popović, Željko D. | |
dc.creator | Janković, Srđa | |
dc.creator | Mojsilović, Slavko | |
dc.date.accessioned | 2023-11-19T08:44:46Z | |
dc.date.available | 2023-11-19T08:44:46Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1010-660X | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1360 | |
dc.description.abstract | Background and Objectives: Oral squamous cell carcinoma (OSCC) accounts for about 95% of oral cancers. It represents a serious public health problem due to the high degree of morbidity and mortality, as well as multifactorial etiology. Human papillomavirus (HPV) infection is a well-documented risk factor for oropharyngeal carcinoma, but its role in oral carcinogenesis is still debatable. Our aim was to investigate the differences in the prevalence of high-risk HPV genotypes (HR-HPV) in patients with OSCC and oral potentially malignant disorders (OPMD) from that of healthy subjects. Materials and Methods: A total of 90 subjects were included in the cross-sectional study and divided into three groups of 30 patients each: (1) patients with OSCC, (2) patients with OPMD, and (3) healthy subjects. We examined the presence of 12 HR-HPV genotypes in the obtained biological material (oral swabs) using real-time PCR. Results: One or more of the 12 tested HR-HPV genotypes were detected in 5/30 patients with OSCC and 2/30 with OPMD, whereas no healthy subjects were positive for any of the tested genotypes. There was a statistically significant difference in nodal involvement between HPV-positive and HPV-negative patients with OSCC. Conclusions: Oral HR-HPV was detected in patients with oral premalignant and malignant lesions but not in healthy individuals, suggesting a possible role in oral carcinogenesis. Broad HR-HPV panel testing could increase the sensitivity of risk assessment and screening for OSCC. | |
dc.language | en | |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Medicina | |
dc.source | Medicina | |
dc.subject | human papillomavirus | |
dc.subject | oral squamous cell carcinoma | |
dc.subject | oral potentially malignant disorders | |
dc.title | High-Risk Human Papillomavirus in Patients with Oral Carcinoma and Oral Potentially Malignant Disorders in Serbia—A Pilot Study | |
dc.type | article | en |
dc.rights.license | BY | |
dc.citation.issue | 10 | |
dc.citation.spage | 1843 | |
dc.citation.volume | 59 | |
dc.identifier.doi | 10.3390/medicina59101843 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/3141/High-Risk_Human_Papillomavirus_in_Patients_with_Oral_Carcinoma_pub_2023.pdf | |
dc.type.version | publishedVersion | |