On the importance of hippocampal segmentation for the neural mapping of memory: Evidence from a large-scale study of neural architecture in healthy adults
Аутори
Vulić, KatarinaBajada, Claude
Paunović, Dunja
Bjekić, Jovana
Filipović, Saša
Sandberg, Kristian
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The hippocampus (HC) is traditionally considered the key neuroanatomical hub responsible for memory. However, previous MRI studies that aimed to relate volumetric hippocampal measures to associative memory (AM) performance have yielded mixed results. In the current study, we aimed to reevaluate these findings in a large sample of young healthy participants (N = 246; age M = 24.95, SD = 4.58; 56% female). Participants were scanned with 3T MAGNETOM Prisma using a 64-channel head coil, followed by the AM assessment in the lab setting. To maximize the scope of AM assessment, we employed four paired-associate tasks of various stimuli modalities (faces, words, scenes) and outcome measure types (recognition, recall). Synthetic T1-weighted images were produced out of relaxometry parameter maps, after which volumetric measures were
calculated using FreeSurfer. The whole HC volume showed no correlation with any of the memory measures. However, further segmentation of HC into its functional and... anatomical subfields (Parasubiculum, Presubiculum, Subiculum, CA1, CA2/3, CA4, GC-DG, HATA, Fimbria, Molecular layer, Hippocampal fissure, Hippocampal tail) showed scattered yet consistent patterns of significant correlations between different subfield volumes and memory outcomes. The results suggest that distinctive contributions of HC subfields may lead to a null effect when the whole HC volume is considered, thus demonstrating that drawing conclusions based on the volumetric measures of neural macrostructures can be misleading. The results highlight the importance of in-depth segmentation for neural mapping.
Извор:
FENS Forum 2022, E-Book of Abstracts, 09-13th July, Paris, France, 2022Институција/група
Institut za medicinska istraživanjaTY - CONF AU - Vulić, Katarina AU - Bajada, Claude AU - Paunović, Dunja AU - Bjekić, Jovana AU - Filipović, Saša AU - Sandberg, Kristian PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1358 AB - The hippocampus (HC) is traditionally considered the key neuroanatomical hub responsible for memory. However, previous MRI studies that aimed to relate volumetric hippocampal measures to associative memory (AM) performance have yielded mixed results. In the current study, we aimed to reevaluate these findings in a large sample of young healthy participants (N = 246; age M = 24.95, SD = 4.58; 56% female). Participants were scanned with 3T MAGNETOM Prisma using a 64-channel head coil, followed by the AM assessment in the lab setting. To maximize the scope of AM assessment, we employed four paired-associate tasks of various stimuli modalities (faces, words, scenes) and outcome measure types (recognition, recall). Synthetic T1-weighted images were produced out of relaxometry parameter maps, after which volumetric measures were calculated using FreeSurfer. The whole HC volume showed no correlation with any of the memory measures. However, further segmentation of HC into its functional and anatomical subfields (Parasubiculum, Presubiculum, Subiculum, CA1, CA2/3, CA4, GC-DG, HATA, Fimbria, Molecular layer, Hippocampal fissure, Hippocampal tail) showed scattered yet consistent patterns of significant correlations between different subfield volumes and memory outcomes. The results suggest that distinctive contributions of HC subfields may lead to a null effect when the whole HC volume is considered, thus demonstrating that drawing conclusions based on the volumetric measures of neural macrostructures can be misleading. The results highlight the importance of in-depth segmentation for neural mapping. C3 - FENS Forum 2022, E-Book of Abstracts, 09-13th July, Paris, France T1 - On the importance of hippocampal segmentation for the neural mapping of memory: Evidence from a large-scale study of neural architecture in healthy adults UR - https://hdl.handle.net/21.15107/rcub_rimi_1358 ER -
@conference{ author = "Vulić, Katarina and Bajada, Claude and Paunović, Dunja and Bjekić, Jovana and Filipović, Saša and Sandberg, Kristian", year = "2022", abstract = "The hippocampus (HC) is traditionally considered the key neuroanatomical hub responsible for memory. However, previous MRI studies that aimed to relate volumetric hippocampal measures to associative memory (AM) performance have yielded mixed results. In the current study, we aimed to reevaluate these findings in a large sample of young healthy participants (N = 246; age M = 24.95, SD = 4.58; 56% female). Participants were scanned with 3T MAGNETOM Prisma using a 64-channel head coil, followed by the AM assessment in the lab setting. To maximize the scope of AM assessment, we employed four paired-associate tasks of various stimuli modalities (faces, words, scenes) and outcome measure types (recognition, recall). Synthetic T1-weighted images were produced out of relaxometry parameter maps, after which volumetric measures were calculated using FreeSurfer. The whole HC volume showed no correlation with any of the memory measures. However, further segmentation of HC into its functional and anatomical subfields (Parasubiculum, Presubiculum, Subiculum, CA1, CA2/3, CA4, GC-DG, HATA, Fimbria, Molecular layer, Hippocampal fissure, Hippocampal tail) showed scattered yet consistent patterns of significant correlations between different subfield volumes and memory outcomes. The results suggest that distinctive contributions of HC subfields may lead to a null effect when the whole HC volume is considered, thus demonstrating that drawing conclusions based on the volumetric measures of neural macrostructures can be misleading. The results highlight the importance of in-depth segmentation for neural mapping.", journal = "FENS Forum 2022, E-Book of Abstracts, 09-13th July, Paris, France", title = "On the importance of hippocampal segmentation for the neural mapping of memory: Evidence from a large-scale study of neural architecture in healthy adults", url = "https://hdl.handle.net/21.15107/rcub_rimi_1358" }
Vulić, K., Bajada, C., Paunović, D., Bjekić, J., Filipović, S.,& Sandberg, K.. (2022). On the importance of hippocampal segmentation for the neural mapping of memory: Evidence from a large-scale study of neural architecture in healthy adults. in FENS Forum 2022, E-Book of Abstracts, 09-13th July, Paris, France. https://hdl.handle.net/21.15107/rcub_rimi_1358
Vulić K, Bajada C, Paunović D, Bjekić J, Filipović S, Sandberg K. On the importance of hippocampal segmentation for the neural mapping of memory: Evidence from a large-scale study of neural architecture in healthy adults. in FENS Forum 2022, E-Book of Abstracts, 09-13th July, Paris, France. 2022;. https://hdl.handle.net/21.15107/rcub_rimi_1358 .
Vulić, Katarina, Bajada, Claude, Paunović, Dunja, Bjekić, Jovana, Filipović, Saša, Sandberg, Kristian, "On the importance of hippocampal segmentation for the neural mapping of memory: Evidence from a large-scale study of neural architecture in healthy adults" in FENS Forum 2022, E-Book of Abstracts, 09-13th July, Paris, France (2022), https://hdl.handle.net/21.15107/rcub_rimi_1358 .