Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males
Аутори
Mitrović-Ajtić, OliveraĐikić, Dragoslava
Subotički, Tijana
Bižić-Radulović, Sandra
Beleslin-Čokić, Bojana
Dragojević, Teodora
Živković, Emilija
Miljatović, Sanja
Vukotić, Milica
Stanisavljević, Dejana
Santibanez, Juan F.
Čokić, Vladan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The severity and mortality of coronavirus disease 2019 (COVID-19) are greater in males than in females, though the infection rate is the same in the two sexes. We investigated sex hormone differences associated with the hyperinflammatory immune response to SARS-CoV-2 on the basis of patients’ cytokine profiles and vaccination statuses. Clinical and laboratory data of 117 patients with COVID-19 were collected to examine sex differences associated with oxidative stress markers, neutrophil extracellular traps (NETs), and plasma cytokine levels up to 5 months from hospital admission. The testosterone and free testosterone levels were low in male patients with COVID-19 and returned to normal values after recovery from the disease. The dihydrotestosterone (DHT) levels were transiently reduced, while the sex hormone-binding globulin levels were decreased in post-COVID-19 male patients. The levels of the inflammatory cytokines interleukin-6 (IL-6) and IL-10 appeared generally increased at diag...nosis and decreased in post-COVID-19 patients. In females, the concentration of tumor necrosis factor-alpha was increased by four times at diagnosis. The levels of the coagulation markers intercellular adhesion molecule-1 (ICAM-1) and E-selectin were consistently upregulated in post-COVID-19 female patients, in contrast to those of vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and chemokine IL-8. DHT increased the levels of reactive oxygen species in the neutrophils of male patients, while estradiol decreased them in females. Markers for NET, such as circulating DNA and myeloperoxidase, were significantly more abundant in the patients’ plasma. Sex hormones have a potential protective role during SARS-CoV-2 infection, which is weakened by impaired testosterone synthesis in men.
Кључне речи:
COVID-19 / sex hormones / vaccine / oxidative stress / cytokinesИзвор:
Vaccines, 2023, 11, 10, 1560-Издавач:
- Multidisciplinary Digital Publishing Institute (MDPI)
Финансирање / пројекти:
- CASHMIR-C19 – Androgen dependent SARS-CoV-2 stimulation of hyperinflammatory response in COVID-19 (RS-ScienceFundRS-Fond_2020_COVID19-7547934)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Mitrović-Ajtić, Olivera AU - Đikić, Dragoslava AU - Subotički, Tijana AU - Bižić-Radulović, Sandra AU - Beleslin-Čokić, Bojana AU - Dragojević, Teodora AU - Živković, Emilija AU - Miljatović, Sanja AU - Vukotić, Milica AU - Stanisavljević, Dejana AU - Santibanez, Juan F. AU - Čokić, Vladan PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1355 AB - The severity and mortality of coronavirus disease 2019 (COVID-19) are greater in males than in females, though the infection rate is the same in the two sexes. We investigated sex hormone differences associated with the hyperinflammatory immune response to SARS-CoV-2 on the basis of patients’ cytokine profiles and vaccination statuses. Clinical and laboratory data of 117 patients with COVID-19 were collected to examine sex differences associated with oxidative stress markers, neutrophil extracellular traps (NETs), and plasma cytokine levels up to 5 months from hospital admission. The testosterone and free testosterone levels were low in male patients with COVID-19 and returned to normal values after recovery from the disease. The dihydrotestosterone (DHT) levels were transiently reduced, while the sex hormone-binding globulin levels were decreased in post-COVID-19 male patients. The levels of the inflammatory cytokines interleukin-6 (IL-6) and IL-10 appeared generally increased at diagnosis and decreased in post-COVID-19 patients. In females, the concentration of tumor necrosis factor-alpha was increased by four times at diagnosis. The levels of the coagulation markers intercellular adhesion molecule-1 (ICAM-1) and E-selectin were consistently upregulated in post-COVID-19 female patients, in contrast to those of vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and chemokine IL-8. DHT increased the levels of reactive oxygen species in the neutrophils of male patients, while estradiol decreased them in females. Markers for NET, such as circulating DNA and myeloperoxidase, were significantly more abundant in the patients’ plasma. Sex hormones have a potential protective role during SARS-CoV-2 infection, which is weakened by impaired testosterone synthesis in men. PB - Multidisciplinary Digital Publishing Institute (MDPI) T2 - Vaccines T2 - Vaccines T1 - Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males IS - 10 SP - 1560 VL - 11 DO - 10.3390/vaccines11101560 ER -
@article{ author = "Mitrović-Ajtić, Olivera and Đikić, Dragoslava and Subotički, Tijana and Bižić-Radulović, Sandra and Beleslin-Čokić, Bojana and Dragojević, Teodora and Živković, Emilija and Miljatović, Sanja and Vukotić, Milica and Stanisavljević, Dejana and Santibanez, Juan F. and Čokić, Vladan", year = "2023", abstract = "The severity and mortality of coronavirus disease 2019 (COVID-19) are greater in males than in females, though the infection rate is the same in the two sexes. We investigated sex hormone differences associated with the hyperinflammatory immune response to SARS-CoV-2 on the basis of patients’ cytokine profiles and vaccination statuses. Clinical and laboratory data of 117 patients with COVID-19 were collected to examine sex differences associated with oxidative stress markers, neutrophil extracellular traps (NETs), and plasma cytokine levels up to 5 months from hospital admission. The testosterone and free testosterone levels were low in male patients with COVID-19 and returned to normal values after recovery from the disease. The dihydrotestosterone (DHT) levels were transiently reduced, while the sex hormone-binding globulin levels were decreased in post-COVID-19 male patients. The levels of the inflammatory cytokines interleukin-6 (IL-6) and IL-10 appeared generally increased at diagnosis and decreased in post-COVID-19 patients. In females, the concentration of tumor necrosis factor-alpha was increased by four times at diagnosis. The levels of the coagulation markers intercellular adhesion molecule-1 (ICAM-1) and E-selectin were consistently upregulated in post-COVID-19 female patients, in contrast to those of vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and chemokine IL-8. DHT increased the levels of reactive oxygen species in the neutrophils of male patients, while estradiol decreased them in females. Markers for NET, such as circulating DNA and myeloperoxidase, were significantly more abundant in the patients’ plasma. Sex hormones have a potential protective role during SARS-CoV-2 infection, which is weakened by impaired testosterone synthesis in men.", publisher = "Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Vaccines, Vaccines", title = "Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males", number = "10", pages = "1560", volume = "11", doi = "10.3390/vaccines11101560" }
Mitrović-Ajtić, O., Đikić, D., Subotički, T., Bižić-Radulović, S., Beleslin-Čokić, B., Dragojević, T., Živković, E., Miljatović, S., Vukotić, M., Stanisavljević, D., Santibanez, J. F.,& Čokić, V.. (2023). Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males. in Vaccines Multidisciplinary Digital Publishing Institute (MDPI)., 11(10), 1560. https://doi.org/10.3390/vaccines11101560
Mitrović-Ajtić O, Đikić D, Subotički T, Bižić-Radulović S, Beleslin-Čokić B, Dragojević T, Živković E, Miljatović S, Vukotić M, Stanisavljević D, Santibanez JF, Čokić V. Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males. in Vaccines. 2023;11(10):1560. doi:10.3390/vaccines11101560 .
Mitrović-Ajtić, Olivera, Đikić, Dragoslava, Subotički, Tijana, Bižić-Radulović, Sandra, Beleslin-Čokić, Bojana, Dragojević, Teodora, Živković, Emilija, Miljatović, Sanja, Vukotić, Milica, Stanisavljević, Dejana, Santibanez, Juan F., Čokić, Vladan, "Sex Differences and Cytokine Profiles among Patients Hospitalized for COVID-19 and during Their Recovery: The Predominance of Adhesion Molecules in Females and Oxidative Stress in Males" in Vaccines, 11, no. 10 (2023):1560, https://doi.org/10.3390/vaccines11101560 . .