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Gait alterations in Parkinson’s disease at the stage of hemiparkinsonism—A longitudinal study
dc.creator | Marković, Vladana | |
dc.creator | Stanković, Iva | |
dc.creator | Radovanović, Saša | |
dc.creator | Petrović, Igor | |
dc.creator | Ječmenica-Lukić, Milica | |
dc.creator | Dragašević-Mišković, Nataša | |
dc.creator | Svetel, Marina | |
dc.creator | Kostić, Vladimir | |
dc.date.accessioned | 2022-08-02T10:41:04Z | |
dc.date.available | 2022-08-02T10:41:04Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1248 | |
dc.description.abstract | Background Progressive gait impairment in Parkinson’s disease (PD) leads to significant disability. Quantitative gait parameters analysis provides valuable information about fine gait alterations. Objectives To analyse change of gait parameters in patients with early PD at the stage of hemiparkinsonism and after 1 year of follow up, taking into account clinical asymmetry. Methods Consecutive early PD outpatients with strictly unilateral motor features underwent clinical and neuropsychological assessment at the study entry and after 1 year of follow up. Gait was assessed with GAITRite walkway using dual-task methodology. Spatiotemporal gait parameters (step time and length, swing time and double support time) and their coefficients of variation (CV), gait velocity and heel-to-heel base support were evaluated. Results We included 42 PD patients with disease duration of 1.3 years (±1.13). Progression of motor and non-motor symptoms, without significant cognitive worsening, was observed after 1 year of follow up. Significant shortening of the swing time, prolongation of the double support and increase of their CVs were observed during all task conditions similarly for most parameters on symptomatic and asymptomatic bodysides, except for CV for the swing time under the combined task. Conclusion Alterations of the swing time and double support time are already present even at the asymptomatic body side, and progress similarly, or even at faster pace, at this side, despite dopaminergic treatment These parameters deserve further investigation in larger, prospective studies to address their potential to serve as markers of progression in interventional disease modifying trials with early PD patients. © 2022 Marković et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.publisher | Public Library of Science | |
dc.relation | This work has been supported by the Ministry of Education, Science, and Technological Development, Republic of Serbia. | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | PLOS ONE | |
dc.subject | Depression | |
dc.subject | Dopaminergics | |
dc.subject | Gait analysis | |
dc.subject | Legs | |
dc.subject | Levodopa | |
dc.subject | Neuropsychological testing | |
dc.subject | Parkinson disease | |
dc.subject | Walking | |
dc.title | Gait alterations in Parkinson’s disease at the stage of hemiparkinsonism—A longitudinal study | |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.issue | 7 | |
dc.citation.spage | e0269886 | |
dc.citation.volume | 17 | |
dc.identifier.doi | 10.1371/journal.pone.0269886 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/2793/bitstream_2793.pdf | |
dc.type.version | publishedVersion |