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The dissociation between virological and immunological responses to HAART
dc.creator | Jevtović, Đorđe | |
dc.creator | Salemović, Dubravka | |
dc.creator | Ranin, Jovan | |
dc.creator | Pešić, I. | |
dc.creator | Zerjav, S | |
dc.creator | Đurković-Đaković, Olgica | |
dc.date.accessioned | 2021-04-20T12:09:05Z | |
dc.date.available | 2021-04-20T12:09:05Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/114 | |
dc.description.abstract | While HAART allows for the reconstitution- of immune functions in most treated HIV patients, discrepant responses including failure to achieve a significant increase in circulating CD4+ T cells despite undetectable plasma viral loads (pVL), or a good immunological response while not reaching undetectabie viremia, may occur. Thus, to evaluate the incidence of and risk factors for discrepant responses to HAART, we conducted a retrospective study of all 446 patients treated with HAART between 1 January 1998 and 31 August 2004 in our HIV unit. CD4+ T cell counts and pVL values at baseline and end of study were parameters of the type of response. Within a mean follow-up period of 33 months, discrepant immunological and virological responses occurred in even 50% patients. Of these, 174(39%) did not have a rise in CD4+ T cells to above 400 per mu l despite a good virological response (type 1 dissociation), while 49 (11.0%) had a rise in the CD4+ T cell count to at least 200 per mu l but their pVL was not undetectable (type 2 dissociation). The risk factors for immunological failure despite an undetectable pVL were baseline CD4+ T cells below 100 per mu l (OR 1.44, 95%CI 1.02-2.03) and HAART composed of three NRTIs (OR 1.92,95% CI 1.35-2.73), while usage of two NRTIs in combination with PI(s) (OR 0.36,95% CI 0.2 6-0.49), as well as simultaneous usage of all three drug classes (OR 0.37, 95% CI 0.26-0.53) were shown to be protective. The usage of PI-containing HAART regimens was protective against type 2 dissociation (OR = 0.40, 95% CI 0.19-0.83). Importantly, there were no differences in the survival of HAART-treated patients irrespective of the type of response. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.rights | restrictedAccess | |
dc.source | Biomedicine & Pharmacotherapy | |
dc.subject | HIV | en |
dc.subject | HAART | en |
dc.subject | virological/immunological dissociation | en |
dc.title | The dissociation between virological and immunological responses to HAART | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 451 | |
dc.citation.issue | 8 | |
dc.citation.other | 59(8): 446-451 | |
dc.citation.rank | M22 | |
dc.citation.spage | 446 | |
dc.citation.volume | 59 | |
dc.identifier.doi | 10.1016/j.biopha.2005.07.006 | |
dc.identifier.pmid | 16140494 | |
dc.identifier.scopus | 2-s2.0-25644432892 | |
dc.identifier.wos | 000232464500004 | |
dc.type.version | publishedVersion |