TY  - JOUR
AU  - Ljujić, Biljana
AU  - Milovanović, Marija
AU  - Volarević, Vladislav
AU  - Murray, Bridgid
AU  - Bugarski, Diana
AU  - Przyborski, Stefan
AU  - Arsenijević, Nebojša
AU  - Lukić, Miodrag L.
AU  - Stojković, Miodrag
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/458
AB  - Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whether injection of hMSC affects tumor appearance, growth and metastasis, and anti-tumor immunity in an experimental animal model of metastatic breast cancer. Injection of hMSC in BALB/c mice bearing mammary carcinoma promoted tumor growth and metastasis, which was accompanied by lower cytotoxic activity of splenocytes, NK cells and CD8(+)T cells in vitro. Tumor-bearing mice that received hMSC had significantly lower percentages of CD3(+)NKp46(+) NKT-like, higher percentages of CD4(+)Foxp3(+) T cells, increased serum levels of Th2 and decreased serum levels of Th1 cytokines, and significantly higher number of CD4(+) cells expressing IL-10. These results demonstrate that immunosuppressive environment created by hMSC promoted breast tumor growth and metastasis in mice.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice
VL  - 3
DO  - 10.1038/srep02298
ER  - 

@article{
author = "Ljujić, Biljana and Milovanović, Marija and Volarević, Vladislav and Murray, Bridgid and Bugarski, Diana and Przyborski, Stefan and Arsenijević, Nebojša and Lukić, Miodrag L. and Stojković, Miodrag",
year = "2013",
abstract = "Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whether injection of hMSC affects tumor appearance, growth and metastasis, and anti-tumor immunity in an experimental animal model of metastatic breast cancer. Injection of hMSC in BALB/c mice bearing mammary carcinoma promoted tumor growth and metastasis, which was accompanied by lower cytotoxic activity of splenocytes, NK cells and CD8(+)T cells in vitro. Tumor-bearing mice that received hMSC had significantly lower percentages of CD3(+)NKp46(+) NKT-like, higher percentages of CD4(+)Foxp3(+) T cells, increased serum levels of Th2 and decreased serum levels of Th1 cytokines, and significantly higher number of CD4(+) cells expressing IL-10. These results demonstrate that immunosuppressive environment created by hMSC promoted breast tumor growth and metastasis in mice.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice",
volume = "3",
doi = "10.1038/srep02298"
}

Ljujić, B., Milovanović, M., Volarević, V., Murray, B., Bugarski, D., Przyborski, S., Arsenijević, N., Lukić, M. L.,& Stojković, M.. (2013). Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. in Scientific Reports
Nature Publishing Group, London., 3.
https://doi.org/10.1038/srep02298

Ljujić B, Milovanović M, Volarević V, Murray B, Bugarski D, Przyborski S, Arsenijević N, Lukić ML, Stojković M. Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. in Scientific Reports. 2013;3.
doi:10.1038/srep02298 .

Ljujić, Biljana, Milovanović, Marija, Volarević, Vladislav, Murray, Bridgid, Bugarski, Diana, Przyborski, Stefan, Arsenijević, Nebojša, Lukić, Miodrag L., Stojković, Miodrag, "Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice" in Scientific Reports, 3 (2013),
https://doi.org/10.1038/srep02298 . .