TY  - JOUR
AU  - Umansky, Viktor
AU  - Adema, Gosse J.
AU  - Baran, Jaroslaw
AU  - Brandau, Sven
AU  - Van Ginderachter, Jo A.
AU  - Hu, Xiaoying
AU  - Jablonska, Jadwiga
AU  - Mojsilović, Slavko
AU  - Papadaki, Helen A.
AU  - de Coana, Yago Pico
AU  - Santegoets, Kim
AU  - Santibanez, Juan F.
AU  - Serre, Karine
AU  - Si, Yu
AU  - Sieminska, Isabela
AU  - Velegraki, Maria
AU  - Fridlender, Zvi G.
PY  - 2019
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/964
AB  - Mounting evidence has accumulated on the critical role of the different myeloid cells in the regulation of the cancerous process, and in particular in the modulation of the immune reaction to cancer. Myeloid cells are a major component of host cells infiltrating tumors, interacting with each other, with tumor cells and other stromal cells, and demonstrating a prominent plasticity. We describe here various myeloid regulatory cells (MRCs) in mice and human as well as their relevant therapeutic targets. We first address the role of the monocytes and macrophages that can contribute to angiogenesis, immunosuppression and metastatic dissemination. Next, we discuss the differential role of neutrophil subsets in tumor development, enhancing the dual and sometimes contradicting role of these cells. A heterogeneous population of immature myeloid cells, MDSCs, was shown to be generated and accumulated during tumor progression as well as to be an important player in cancer-related immune suppression. Lastly, we discuss the role of myeloid DCs, which can either contribute to effective anti-tumor responses or play a more regulatory role. We believe that MRCs play a critical role in cancer-related immune regulation and suggest that future anti-cancer therapies will focus on these abundant cells.
PB  - Springer, New York
T2  - Cancer Immunology Immunotherapy
T1  - Interactions among myeloid regulatory cells in cancer
EP  - 660
IS  - 4
SP  - 645
VL  - 68
DO  - 10.1007/s00262-018-2200-6
ER  - 

@article{
author = "Umansky, Viktor and Adema, Gosse J. and Baran, Jaroslaw and Brandau, Sven and Van Ginderachter, Jo A. and Hu, Xiaoying and Jablonska, Jadwiga and Mojsilović, Slavko and Papadaki, Helen A. and de Coana, Yago Pico and Santegoets, Kim and Santibanez, Juan F. and Serre, Karine and Si, Yu and Sieminska, Isabela and Velegraki, Maria and Fridlender, Zvi G.",
year = "2019",
abstract = "Mounting evidence has accumulated on the critical role of the different myeloid cells in the regulation of the cancerous process, and in particular in the modulation of the immune reaction to cancer. Myeloid cells are a major component of host cells infiltrating tumors, interacting with each other, with tumor cells and other stromal cells, and demonstrating a prominent plasticity. We describe here various myeloid regulatory cells (MRCs) in mice and human as well as their relevant therapeutic targets. We first address the role of the monocytes and macrophages that can contribute to angiogenesis, immunosuppression and metastatic dissemination. Next, we discuss the differential role of neutrophil subsets in tumor development, enhancing the dual and sometimes contradicting role of these cells. A heterogeneous population of immature myeloid cells, MDSCs, was shown to be generated and accumulated during tumor progression as well as to be an important player in cancer-related immune suppression. Lastly, we discuss the role of myeloid DCs, which can either contribute to effective anti-tumor responses or play a more regulatory role. We believe that MRCs play a critical role in cancer-related immune regulation and suggest that future anti-cancer therapies will focus on these abundant cells.",
publisher = "Springer, New York",
journal = "Cancer Immunology Immunotherapy",
title = "Interactions among myeloid regulatory cells in cancer",
pages = "660-645",
number = "4",
volume = "68",
doi = "10.1007/s00262-018-2200-6"
}

Umansky, V., Adema, G. J., Baran, J., Brandau, S., Van Ginderachter, J. A., Hu, X., Jablonska, J., Mojsilović, S., Papadaki, H. A., de Coana, Y. P., Santegoets, K., Santibanez, J. F., Serre, K., Si, Y., Sieminska, I., Velegraki, M.,& Fridlender, Z. G.. (2019). Interactions among myeloid regulatory cells in cancer. in Cancer Immunology Immunotherapy
Springer, New York., 68(4), 645-660.
https://doi.org/10.1007/s00262-018-2200-6

Umansky V, Adema GJ, Baran J, Brandau S, Van Ginderachter JA, Hu X, Jablonska J, Mojsilović S, Papadaki HA, de Coana YP, Santegoets K, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG. Interactions among myeloid regulatory cells in cancer. in Cancer Immunology Immunotherapy. 2019;68(4):645-660.
doi:10.1007/s00262-018-2200-6 .

Umansky, Viktor, Adema, Gosse J., Baran, Jaroslaw, Brandau, Sven, Van Ginderachter, Jo A., Hu, Xiaoying, Jablonska, Jadwiga, Mojsilović, Slavko, Papadaki, Helen A., de Coana, Yago Pico, Santegoets, Kim, Santibanez, Juan F., Serre, Karine, Si, Yu, Sieminska, Isabela, Velegraki, Maria, Fridlender, Zvi G., "Interactions among myeloid regulatory cells in cancer" in Cancer Immunology Immunotherapy, 68, no. 4 (2019):645-660,
https://doi.org/10.1007/s00262-018-2200-6 . .