TY  - JOUR
AU  - Vukotić, Milica
AU  - Kapor, Sunčica
AU  - Simon, Felipe
AU  - Čokić, Vladan
AU  - Santibanez, Juan F.
PY  - 2024
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1458
AB  - Myeloid malignancies are clonal disorders of the progenitor cells or hematopoietic stem cells, including acute myeloid leukemia, myelodysplastic syndromes, myeloproliferative malignancies, and chronic myelomonocytic leukemia. Myeloid neoplastic cells affect the proliferation and dif- ferentiation of other hematopoietic lineages in the bone marrow and peripheral blood, leading to severe and life-threatening complications. Mesenchymal stromal cells (MSCs) residing in the bone marrow exert immunosuppressive functions by suppressing innate and adaptive immune systems, thus creating a supportive and tolerant microenvironment for myeloid malignancy progression. This review summarizes the significant features of MSCs in myeloid malignancies, including their role in regulating cell growth, cell death, and antineoplastic resistance, in addition to their immunosuppressive contributions. Understanding the implications of MSCs in myeloid malig- nancies could pave the path for potential use in immunotherapy.
PB  - Elsevier
T2  - Heliyon
T1  - Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities
IS  - 3
SP  - e25081
VL  - 10
DO  - 10.1016/j.heliyon.2024.e25081
ER  - 

@article{
author = "Vukotić, Milica and Kapor, Sunčica and Simon, Felipe and Čokić, Vladan and Santibanez, Juan F.",
year = "2024",
abstract = "Myeloid malignancies are clonal disorders of the progenitor cells or hematopoietic stem cells, including acute myeloid leukemia, myelodysplastic syndromes, myeloproliferative malignancies, and chronic myelomonocytic leukemia. Myeloid neoplastic cells affect the proliferation and dif- ferentiation of other hematopoietic lineages in the bone marrow and peripheral blood, leading to severe and life-threatening complications. Mesenchymal stromal cells (MSCs) residing in the bone marrow exert immunosuppressive functions by suppressing innate and adaptive immune systems, thus creating a supportive and tolerant microenvironment for myeloid malignancy progression. This review summarizes the significant features of MSCs in myeloid malignancies, including their role in regulating cell growth, cell death, and antineoplastic resistance, in addition to their immunosuppressive contributions. Understanding the implications of MSCs in myeloid malig- nancies could pave the path for potential use in immunotherapy.",
publisher = "Elsevier",
journal = "Heliyon",
title = "Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities",
number = "3",
pages = "e25081",
volume = "10",
doi = "10.1016/j.heliyon.2024.e25081"
}

Vukotić, M., Kapor, S., Simon, F., Čokić, V.,& Santibanez, J. F.. (2024). Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities. in Heliyon
Elsevier., 10(3), e25081.
https://doi.org/10.1016/j.heliyon.2024.e25081

Vukotić M, Kapor S, Simon F, Čokić V, Santibanez JF. Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities. in Heliyon. 2024;10(3):e25081.
doi:10.1016/j.heliyon.2024.e25081 .

Vukotić, Milica, Kapor, Sunčica, Simon, Felipe, Čokić, Vladan, Santibanez, Juan F., "Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities" in Heliyon, 10, no. 3 (2024):e25081,
https://doi.org/10.1016/j.heliyon.2024.e25081 . .