TY  - JOUR
AU  - Defrin, Ruth
AU  - Amanzio, Martina
AU  - de Tommaso, Marina
AU  - Dimova, Violeta
AU  - Filipović, Saša
AU  - Finn, David P.
AU  - Gimenez-Llort, Lydia
AU  - Invitto, Sara
AU  - Jensen-Dahm, Christina
AU  - Lautenbacher, Stefan
AU  - Oosterman, Joukje M.
AU  - Petrini, Laura
AU  - Pick, Chaim G.
AU  - Pickering, Gisele
AU  - Vase, Lene
AU  - Kunz, Miriam
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/671
AB  - Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Pain
T1  - Experimental pain processing in individuals with cognitive impairment: current state of the science
EP  - 1408
IS  - 8
SP  - 1396
VL  - 156
DO  - 10.1097/j.pain.0000000000000195
ER  - 

@article{
author = "Defrin, Ruth and Amanzio, Martina and de Tommaso, Marina and Dimova, Violeta and Filipović, Saša and Finn, David P. and Gimenez-Llort, Lydia and Invitto, Sara and Jensen-Dahm, Christina and Lautenbacher, Stefan and Oosterman, Joukje M. and Petrini, Laura and Pick, Chaim G. and Pickering, Gisele and Vase, Lene and Kunz, Miriam",
year = "2015",
abstract = "Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Pain",
title = "Experimental pain processing in individuals with cognitive impairment: current state of the science",
pages = "1408-1396",
number = "8",
volume = "156",
doi = "10.1097/j.pain.0000000000000195"
}

Defrin, R., Amanzio, M., de Tommaso, M., Dimova, V., Filipović, S., Finn, D. P., Gimenez-Llort, L., Invitto, S., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J. M., Petrini, L., Pick, C. G., Pickering, G., Vase, L.,& Kunz, M.. (2015). Experimental pain processing in individuals with cognitive impairment: current state of the science. in Pain
Lippincott Williams & Wilkins, Philadelphia., 156(8), 1396-1408.
https://doi.org/10.1097/j.pain.0000000000000195

Defrin R, Amanzio M, de Tommaso M, Dimova V, Filipović S, Finn DP, Gimenez-Llort L, Invitto S, Jensen-Dahm C, Lautenbacher S, Oosterman JM, Petrini L, Pick CG, Pickering G, Vase L, Kunz M. Experimental pain processing in individuals with cognitive impairment: current state of the science. in Pain. 2015;156(8):1396-1408.
doi:10.1097/j.pain.0000000000000195 .

Defrin, Ruth, Amanzio, Martina, de Tommaso, Marina, Dimova, Violeta, Filipović, Saša, Finn, David P., Gimenez-Llort, Lydia, Invitto, Sara, Jensen-Dahm, Christina, Lautenbacher, Stefan, Oosterman, Joukje M., Petrini, Laura, Pick, Chaim G., Pickering, Gisele, Vase, Lene, Kunz, Miriam, "Experimental pain processing in individuals with cognitive impairment: current state of the science" in Pain, 156, no. 8 (2015):1396-1408,
https://doi.org/10.1097/j.pain.0000000000000195 . .

TY  - JOUR
AU  - Defrin, Ruth
AU  - Amanzio, Martina
AU  - de Tommaso, Marina
AU  - Dimova, Violeta
AU  - Filipović, Saša
AU  - Finn, David P.
AU  - Gimenez-Llort, Lydia
AU  - Invitto, Sara
AU  - Jensen-Dahm, Christina
AU  - Lautenbacher, Stefan
AU  - Oosterman, Joukje M.
AU  - Petrini, Laura
AU  - Pick, Chaim G.
AU  - Pickering, Gisele
AU  - Vase, Lene
AU  - Kunz, Miriam
PY  - 2015
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1131
AB  - Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Pain
T1  - Experimental pain processing in individuals with cognitive impairment: current state of the science
EP  - 1408
IS  - 8
SP  - 1396
VL  - 156
DO  - 10.1097/j.pain.0000000000000195
ER  - 

@article{
author = "Defrin, Ruth and Amanzio, Martina and de Tommaso, Marina and Dimova, Violeta and Filipović, Saša and Finn, David P. and Gimenez-Llort, Lydia and Invitto, Sara and Jensen-Dahm, Christina and Lautenbacher, Stefan and Oosterman, Joukje M. and Petrini, Laura and Pick, Chaim G. and Pickering, Gisele and Vase, Lene and Kunz, Miriam",
year = "2015",
abstract = "Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Pain",
title = "Experimental pain processing in individuals with cognitive impairment: current state of the science",
pages = "1408-1396",
number = "8",
volume = "156",
doi = "10.1097/j.pain.0000000000000195"
}

Defrin, R., Amanzio, M., de Tommaso, M., Dimova, V., Filipović, S., Finn, D. P., Gimenez-Llort, L., Invitto, S., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J. M., Petrini, L., Pick, C. G., Pickering, G., Vase, L.,& Kunz, M.. (2015). Experimental pain processing in individuals with cognitive impairment: current state of the science. in Pain
Lippincott Williams & Wilkins, Philadelphia., 156(8), 1396-1408.
https://doi.org/10.1097/j.pain.0000000000000195

Defrin R, Amanzio M, de Tommaso M, Dimova V, Filipović S, Finn DP, Gimenez-Llort L, Invitto S, Jensen-Dahm C, Lautenbacher S, Oosterman JM, Petrini L, Pick CG, Pickering G, Vase L, Kunz M. Experimental pain processing in individuals with cognitive impairment: current state of the science. in Pain. 2015;156(8):1396-1408.
doi:10.1097/j.pain.0000000000000195 .

Defrin, Ruth, Amanzio, Martina, de Tommaso, Marina, Dimova, Violeta, Filipović, Saša, Finn, David P., Gimenez-Llort, Lydia, Invitto, Sara, Jensen-Dahm, Christina, Lautenbacher, Stefan, Oosterman, Joukje M., Petrini, Laura, Pick, Chaim G., Pickering, Gisele, Vase, Lene, Kunz, Miriam, "Experimental pain processing in individuals with cognitive impairment: current state of the science" in Pain, 156, no. 8 (2015):1396-1408,
https://doi.org/10.1097/j.pain.0000000000000195 . .