TY  - JOUR
AU  - Santibanez, Juan F.
AU  - Obradović, Hristina
AU  - Kukolj, Tamara
AU  - Krstić, Jelena
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/870
AB  - Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.
PB  - Wiley, Hoboken
T2  - Developmental Dynamics
T1  - Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
EP  - 395
IS  - 3
SP  - 382
VL  - 247
DO  - 10.1002/dvdy.24554
ER  - 

@article{
author = "Santibanez, Juan F. and Obradović, Hristina and Kukolj, Tamara and Krstić, Jelena",
year = "2018",
abstract = "Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.",
publisher = "Wiley, Hoboken",
journal = "Developmental Dynamics",
title = "Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition",
pages = "395-382",
number = "3",
volume = "247",
doi = "10.1002/dvdy.24554"
}

Santibanez, J. F., Obradović, H., Kukolj, T.,& Krstić, J.. (2018). Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. in Developmental Dynamics
Wiley, Hoboken., 247(3), 382-395.
https://doi.org/10.1002/dvdy.24554

Santibanez JF, Obradović H, Kukolj T, Krstić J. Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. in Developmental Dynamics. 2018;247(3):382-395.
doi:10.1002/dvdy.24554 .

Santibanez, Juan F., Obradović, Hristina, Kukolj, Tamara, Krstić, Jelena, "Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition" in Developmental Dynamics, 247, no. 3 (2018):382-395,
https://doi.org/10.1002/dvdy.24554 . .