TY  - JOUR
AU  - Knez, Marija
AU  - Stangoulis, James C. R.
AU  - Zec, Manja M.
AU  - Debeljak-Martačić, Jasmina
AU  - Pavlović, Zoran
AU  - Gurinović, Mirjana
AU  - Glibetić, Marija
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/706
AB  - Background: Zinc is an essential micronutrient for humans with important physiological functions. A sensitive and specific biomarker for assessing Zn status is still needed. Objective: The major aim of this study was to examine if the changes in the content of plasma phospholipid LA, DGLA and LA: DGLA ratio can be used to efficiently predict the dietary Zn intake and plasma Zn status of humans. Methods: The study was performed on healthy human volunteers, 25-55 years of age. The dietary Zn intake was assessed using 24 h recall questionnaires. Plasma phospholipid fatty acid analysis was done by gas chromatography, and plasma analysis of minerals by atomic absorption spectrometry. Biochemical, anthropometrical and hematological parameters were assessed. Results: No significant relationship was found between the dietary and plasma zinc status (r = 0.07; p = 0.6). There was a statistically significant correlation between DGLA and plasma Zn (r = 0.39, p = 0.00). No relationship was observed between the linoleic acid and plasma Zn, while there was a significant negative correlation between LA: DGLA ratio and plasma Zn status (r = 0.35, p = 0.01). Similarly, there were statistically significant difference in DGLA status (p = 0.004) and LA: DGLA ratio (p = 0.042) between the Zn formed groups. Conclusions: This study is an initial step in evaluating LA: DGLA ratio as a biomarker of Zn status in humans. The results are encouraging as they show that concentration of DGLA is decreased and LA: DGLA ratio increased in people with lower dietary Zn intake. However, additional studies are needed to fully examine the sensitivity of this biomarker.
PB  - Elsevier Science Bv, Amsterdam
T2  - Clinical Nutrition ESPEN
T1  - An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio
EP  - 92
SP  - 85
VL  - 15
DO  - 10.1016/j.clnesp.2016.06.013
ER  - 

@article{
author = "Knez, Marija and Stangoulis, James C. R. and Zec, Manja M. and Debeljak-Martačić, Jasmina and Pavlović, Zoran and Gurinović, Mirjana and Glibetić, Marija",
year = "2016",
abstract = "Background: Zinc is an essential micronutrient for humans with important physiological functions. A sensitive and specific biomarker for assessing Zn status is still needed. Objective: The major aim of this study was to examine if the changes in the content of plasma phospholipid LA, DGLA and LA: DGLA ratio can be used to efficiently predict the dietary Zn intake and plasma Zn status of humans. Methods: The study was performed on healthy human volunteers, 25-55 years of age. The dietary Zn intake was assessed using 24 h recall questionnaires. Plasma phospholipid fatty acid analysis was done by gas chromatography, and plasma analysis of minerals by atomic absorption spectrometry. Biochemical, anthropometrical and hematological parameters were assessed. Results: No significant relationship was found between the dietary and plasma zinc status (r = 0.07; p = 0.6). There was a statistically significant correlation between DGLA and plasma Zn (r = 0.39, p = 0.00). No relationship was observed between the linoleic acid and plasma Zn, while there was a significant negative correlation between LA: DGLA ratio and plasma Zn status (r = 0.35, p = 0.01). Similarly, there were statistically significant difference in DGLA status (p = 0.004) and LA: DGLA ratio (p = 0.042) between the Zn formed groups. Conclusions: This study is an initial step in evaluating LA: DGLA ratio as a biomarker of Zn status in humans. The results are encouraging as they show that concentration of DGLA is decreased and LA: DGLA ratio increased in people with lower dietary Zn intake. However, additional studies are needed to fully examine the sensitivity of this biomarker.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Clinical Nutrition ESPEN",
title = "An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio",
pages = "92-85",
volume = "15",
doi = "10.1016/j.clnesp.2016.06.013"
}

Knez, M., Stangoulis, J. C. R., Zec, M. M., Debeljak-Martačić, J., Pavlović, Z., Gurinović, M.,& Glibetić, M.. (2016). An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio. in Clinical Nutrition ESPEN
Elsevier Science Bv, Amsterdam., 15, 85-92.
https://doi.org/10.1016/j.clnesp.2016.06.013

Knez M, Stangoulis JCR, Zec MM, Debeljak-Martačić J, Pavlović Z, Gurinović M, Glibetić M. An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio. in Clinical Nutrition ESPEN. 2016;15:85-92.
doi:10.1016/j.clnesp.2016.06.013 .

Knez, Marija, Stangoulis, James C. R., Zec, Manja M., Debeljak-Martačić, Jasmina, Pavlović, Zoran, Gurinović, Mirjana, Glibetić, Marija, "An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-y-linolenic acid (LA:DGLA) ratio" in Clinical Nutrition ESPEN, 15 (2016):85-92,
https://doi.org/10.1016/j.clnesp.2016.06.013 . .